Integrated in-depth bioinformatic analysis suggests RELCH/KIAA1468, LINC02341, and AKAP11 as candidate genes for ages at menarche and menopause

V. Dvornyk
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引用次数: 0

Abstract

Polymorphisms of the TNFRSF11A and TNFSF11 genes were reported for their association with age at menarche (AAM) and age at natural menopause (ANM). However, the biological mechanisms underlying this association remain largely unclear. The aim of the study: This study was to determine biological processes backing the observed genetic associations. Materials and methods: Fortyfour SNPs were analyzed using in silico approach and ten publicly available online databases and tools. Results: TNFRSF11A and TNFSF11 are highly pleiotropic genes that play a role in many metabolic processes. However, among that variety, lipid metabolism and cell survival and apoptosis seem the most biologically plausible mechanisms, through which these genes contribute to AAM and ANM. The analysis identified several mechanisms underlying the previously determined association of the TNFRSF11A and TNFSF11 genes with AAM and ANM and suggested RELCH/KIAA1468, LINC02341, and AKAP11 as new candidate genes for the traits.
综合深入的生物信息学分析表明,RELCH/KIAA1468、LINC02341和AKAP11是影响月经初潮和更年期年龄的候选基因
据报道,TNFRSF11A和TNFSF11基因的多态性与月经初潮年龄(AAM)和自然绝经年龄(ANM)有关。然而,这种关联背后的生物学机制在很大程度上仍不清楚。这项研究的目的是确定支持观察到的遗传关联的生物学过程。材料和方法:使用计算机方法和10个公开的在线数据库和工具分析了44个snp。结果:TNFRSF11A和TNFSF11是高度多效性基因,在多种代谢过程中发挥作用。然而,在这些基因中,脂质代谢和细胞存活和凋亡似乎是生物学上最合理的机制,这些基因通过这些机制参与AAM和ANM。该分析确定了TNFRSF11A和TNFSF11基因与AAM和ANM关联的几种机制,并建议RELCH/KIAA1468、LINC02341和AKAP11作为这些性状的新候选基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
自引率
0.00%
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0
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