Differentia Effects Of Calabash Chalk On The Histology Of The Liver Of Adult Wister Rats

Abstract

The environment we live contains different chemicals we consume oblivious of its detrimental effects. One of such is calabash chalk. This study was to ascertain the effect of two commonly available preparation of this chalk on the histology of the liver of adult Wistar rats. Twenty-four adult female Wistar rats of weight 90-110g were assigned into two groups (1, 2, and 3). Group 1 was the control and the animals received distilled water, while groups 2 and 3 were treated by oral gavage each with 40mg/kg of non-salted and salted calabash chalk respectively for 14 days. The liver sections of the non-salted group showed sinusoids enlargement and fragmented parenchyma, while the salted group presented no obvious pathology compared to the control. Besides liver histological and may be functional damage, this may prone the liver to susceptibility to other form of toxins. We thus infer that the non-salted calabash chalk is detrimental to health unlike the salted calabash chalk.