Histaminergic neurotransmission as a gateway for the effects of the fat sensing molecule Oleoylethanolamide

Alessia Costa
{"title":"Histaminergic neurotransmission as a gateway for the effects of the fat sensing molecule Oleoylethanolamide","authors":"Alessia Costa","doi":"10.36253/978-88-6453-995-9","DOIUrl":null,"url":null,"abstract":"The histaminergic system is a pleiotropic system that commands general states of metabolism and consciousness, including learning and memorizing both pleasurable and aversive events. Brain histamine mediates the central effects of a signal molecule produced in the intestine, namely oleoylethanolamide (OEA). OEA is released by the enterocytes in response to high fat intake and reduces eating, by indirectly activating a subpopulation of histaminergic neurons. In her thesis, she explored other potential interactions between these two systems in the pursuit of unexplored neuronal mechanisms that may shed light on the mode of action of psychoactive agents and possibly lead to the development of new drugs.","PeriodicalId":20330,"journal":{"name":"Premio Tesi di Dottorato","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Premio Tesi di Dottorato","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36253/978-88-6453-995-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

The histaminergic system is a pleiotropic system that commands general states of metabolism and consciousness, including learning and memorizing both pleasurable and aversive events. Brain histamine mediates the central effects of a signal molecule produced in the intestine, namely oleoylethanolamide (OEA). OEA is released by the enterocytes in response to high fat intake and reduces eating, by indirectly activating a subpopulation of histaminergic neurons. In her thesis, she explored other potential interactions between these two systems in the pursuit of unexplored neuronal mechanisms that may shed light on the mode of action of psychoactive agents and possibly lead to the development of new drugs.
组胺能神经传递作为脂肪感应分子油脂乙醇酰胺作用的通道
组胺能系统是一个多效系统,它控制着新陈代谢和意识的一般状态,包括学习和记忆愉快和厌恶的事件。脑组胺介导肠内产生的一种信号分子的中枢作用,即油基乙醇酰胺(OEA)。肠细胞通过间接激活组胺能神经元亚群,在摄入高脂肪和减少进食的情况下释放OEA。在她的论文中,她探索了这两个系统之间其他潜在的相互作用,以追求未被探索的神经元机制,这可能会揭示精神活性药物的作用模式,并可能导致新药的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信