Effects of Platelet Rich Plasma in Combination with Hyaluronic Acid in the Treatment of Primary Knee Osteoarthritis

Journal of National Institute of Neurosciences Bangladesh Pub Date : 2019-09-07 DOI:10.3329/jninb.v5i2.43018

Saydur Rahman, Syed Ariful Islam, Jobayer Hossain, M. S. Arefin, Imrul Islam, Sharmin Ara Begum, Shofina Sultana Shompa, Akm Akhtaruzzaman

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引用次数: 2

Abstract

Background: Platelet Rich Plasma (PRP) is increasingly applied in clinical practice to treat knee degenerative pathology. Both PRP and hyaluronic acid (HA) have been extensively used to improve lubrication, modulate inflammation and modify the catabolic micro-environment of the joint. Objective: This study was aimed to evaluate the potential synergistic effects of PRP in combination with hyaluronic acid in primary knee osteoarthritis. Methodology: This randomized control trial was carried out on adult patients with primary knee osteoarthritis who attended the Pain Clinic of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, during the period of September 2015 to August 2017. The patients were randomly assigned to one of the two groups designated as group P (control group) who were only treated with PRP and group PH (experimental group) who were treated with the combination of PRP and hyaluronic acid. After providing the allocated treatment, all patients were undergone follow-up examination at 1st week, 1st month and 3rd month for pain improvement by VAS scale and for functional improvement by International Knee Documentation Committee (IKDC) score. Results: A total number of 34 patients were recruited for this study. Visual analogue score 1st month (5.85±0.83) and 3rd month (3.01±0.12) follow up showed statistically significant difference among two group (p=0.001). Inter group comparison showed that, mean VAS score of group PH (3.01±0.12) decreased more than Group P (4.01±1.01). In case of functional improvement, group PH also showed statistically better improvement during 1st month (45.76±3.25) and 3rd month (62.06±5.37) follow up than Group P. Conclusion: In conclusion articular platelet rich plasma in combination with hyaluronic acid provide better pain relief and improvement of functional status than PRP therapy alone in primary knee osteoarthritis. Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 137-142

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富血小板血浆联合透明质酸治疗原发性膝骨关节炎的疗效观察

背景:富血小板血浆(PRP)越来越多地应用于临床治疗膝关节退行性病理。PRP和透明质酸(HA)都被广泛用于改善关节的润滑、调节炎症和改变关节的分解代谢微环境。目的:探讨PRP联合透明质酸治疗原发性膝骨关节炎的潜在协同作用。方法:本随机对照试验于2015年9月至2017年8月在孟加拉国达卡Bangabandhu Sheikh Mujib医科大学疼痛诊所就诊的原发性膝关节骨关节炎成年患者进行。将患者随机分为两组，分别为P组(对照组)和PH组(实验组)，P组只接受PRP治疗，PH组同时接受PRP和透明质酸治疗。所有患者在完成分配的治疗后，于第1周、第1个月和第3个月进行随访检查，根据VAS评分进行疼痛改善，根据国际膝关节文献委员会(International Knee Documentation Committee, IKDC)评分进行功能改善。结果:本研究共招募34例患者。视觉模拟评分随访第1个月(5.85±0.83)、第3个月(3.01±0.12)，两组比较差异有统计学意义(p=0.001)。组间比较显示，PH组VAS平均评分(3.01±0.12)低于P组(4.01±1.01)。在功能改善方面，PH组随访第1个月(45.76±3.25)和第3个月(62.06±5.37)均优于p组。结论:关节富血小板血浆联合透明质酸治疗原发性膝骨性关节炎的疼痛缓解和功能改善效果优于单纯PRP治疗。孟加拉国国家神经科学研究所学报，2019;5(2):137-142

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Journal of National Institute of Neurosciences Bangladesh

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