Cardiohepatic interactions in heart failure: clinical and therapeutic implications

Continuing Cardiology Education Pub Date : 2017-10-09 DOI:10.1002/cce2.63

M. Nikolaou, A. Mebazaa

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引用次数: 7

Abstract

Liver involvement in chronic heart failure has long been recognized and reflects the systemic hemodynamic changes that occur during the evolution of heart failure syndrome. Apart from venous congestion and backward failure, other fundamental mechanisms also exist such as decreased hepatic blood flow, decreased arterial saturation, and sinusoidal thrombosis. In the acute setting, the decrease in cardiac output, accompanied by severe and profound hypotension is the main cause of acute liver injury, whereas increased venous pressure also plays an important role. The biochemical dominance of a cholestatic profile is rather related to congestion and increased systemic venous pressures, whereas the hepatotoxic profile is rather related to hypoperfusion.

Answer questions and earn CME: https://wileyhealthlearning.com/Activity2/5608949/Activity.aspx

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心力衰竭的肝心相互作用:临床和治疗意义

慢性心力衰竭的肝脏受累早已被认识到，它反映了心力衰竭综合征演变过程中发生的全身血流动力学变化。除了静脉充血、后向衰竭外，还有肝血流量减少、动脉饱和度降低、窦内血栓形成等基本机制。在急性情况下，心输出量减少并伴有严重和深度低血压是急性肝损伤的主要原因，而静脉压升高也起重要作用。胆汁淤积特征的生化优势与充血和全身静脉压升高有关，而肝毒性特征与灌注不足有关。回答问题并获得CME: https://wileyhealthlearning.com/Activity2/5608949/Activity.aspx

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Continuing Cardiology Education

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