PHYSIOLOGICAL STATUS OF REPRODUCTIVE AGE GIRLS UNDER CONDITIONS OF TECHNOGENIC IMPACT IN THE KOLA NORTH

Abstract

Introduction. Reproductive health disorders in adolescent girls in the Kola North, the lack of studies of the physiological status of reproductive age girls living in the territory with high pollution by dust particles of apatite-nepheline ore, determine the relevance of this study, involving the identification of indicators of premorbid state. Objective. To estimate the physiological status of reproductive age girls living under chronic stress condition caused by exposure to anthropogenic and Arctic environment, to reveal possible prenosological deviations as indicators of premorbid state. Methods. The study design was an observational, analytic, cross-sectional, cohort study in 3 observational series: 2019, 2020, 2021, involving 54 female medical college students 16-20 years living in Apatity. Territorial morbidity of adolescents was analyzed on the basis of data from the MIAC of the Murmansk Regional Clinical Hospital named after P.A. Bayandin. Physiological status was assessed on the basis of the content of hypothalamic-pituitary-adrenocortical system (HPACS) hormones, metabolites of lipid peroxidation, antioxidant protection (AOP), vitamin D, lipids, carbohydrates using percentile distribution of indicator values. Significance of the differences was determined by Mann-Whitney U test, Kolmogorov-Smirnov test, t-criterion for independent samples. Results. It was shown that morbidity in adolescents with circulatory system diseases, skin and subcutaneous tissue diseases (atopic dermatitis), urogenital system diseases in Apatity exceeds corresponding values in other industrial polluted territories of the Murmansk region. Early effects of chronic exposure of the body to dust particles were revealed in more than 25% of the girls, which manifested themselves in increased secretion of adrenocorticotropic hormone, cortisol, thyrotropic hormone, in decreased somatotropic hormone, thyroxine, in reduced content of AOS enzymes. Hypovitaminosis of vitamin D was detected in 95% of girls, low values of low density lipoproteins was found in 50% of girls. Conclusion. Pre-nosological deviations of the physiological status in the conditions of technogenic pollution testify to the oppression of the body's protective systems and are predictors of morbidity and are subject to individual correction.