Lipase as Biocatalyst- for Synthesis of Phenol by Using Box–Behnken Design

IF 2.4 3区 化学 Q2 CHEMISTRY, ORGANIC
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Abstract

This work highlighted the proficient and naturally safe methodology for the phenol synthesis using biocatalyst lipase. The development of sustainable synthetic protocol for various organic transformations is an important area of research attracts researchers to avoid use of volatile and hazardous organic solvents in reaction for greener and eco-friendly protocols. Lipase is subclass of esterase enzymes and acts as biocatalyst with industrial significance. They carry out biochemical transformation in non-aqueous and aqueous phases quickly. To further make the process more specific Design Expert software was used for the optimization of synthesize phenol for maximum % Yield and % Purity. Effect of temperature, Concentration of Catalyst, and Volume of Water was selected as an independent factor to get the maximum % Yield and % Purity of the phenol. The results confirmed the mathematical model robustness and justify experimental design. Therefore, the current protocol for synthesis of phenols from phenylboronic acid is greenest and environmentally benign alternative. The current convention has many benefits, like phenomenal product yields, reduced time of reaction, simple procedure to work up, and extensive substrate scope, cost-effective and also lipase was recuperated and reused multiple times without significant loss of its catalytic activity.

利用盒式贝肯设计将脂肪酶作为生物催化剂合成苯酚
这项工作强调了利用生物催化剂脂肪酶合成苯酚的熟练和自然安全的方法。为各种有机转化开发可持续的合成方案是一个重要的研究领域,它吸引着研究人员避免在反应中使用挥发性和有害的有机溶剂,以实现更环保和生态友好的方案。脂肪酶是酯酶的一个亚类,是一种具有工业意义的生物催化剂。它们能在非水相和水相中快速进行生化转化。为了进一步提高工艺的针对性,我们使用 Design Expert 软件对苯酚的合成进行了优化,以获得最高的产率和纯度。选择温度、催化剂浓度和水体积作为独立因素,以获得苯酚的最大产率和纯度。结果证实了数学模型的稳健性和实验设计的合理性。因此,目前从苯硼酸合成苯酚的方案是最绿色环保的选择。目前的方法有许多优点,如产品产量高、反应时间短、操作程序简单、底物范围广、成本效益高,而且脂肪酶可以多次回收和重复使用,其催化活性不会明显减弱。
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来源期刊
Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds 化学-有机化学
CiteScore
3.70
自引率
20.80%
发文量
412
审稿时长
3 months
期刊介绍: The purpose of Polycyclic Aromatic Compounds is to provide an international and interdisciplinary forum for all aspects of research related to polycyclic aromatic compounds (PAC). Topics range from fundamental research in chemistry (including synthetic and theoretical chemistry) and physics (including astrophysics), as well as thermodynamics, spectroscopy, analytical methods, and biology to applied studies in environmental science, biochemistry, toxicology, and industry. Polycyclic Aromatic Compounds has an outstanding Editorial Board and offers a rapid and efficient peer review process, as well as a flexible open access policy.
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