Biochemical Markers As Predictor Of Preterm Labor- Their Clinical Relevance And The Current Status

Suneeta Singh, M. Dey, Sanjay Singh, S. Sasidharan
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引用次数: 2

Abstract

Preterm birth is associated with significant perinatal morbidity and mortality. Spontaneous preterm birth accounts for upto 75% of all preterm births. A number of maternal and fetal characteristics have been associated with preterm birth. With better understanding of the pathophysiology of preterm birth, various biochemical markers have been studied extensively to predict the preterm birth efficiently so as to intervene appropriately and timely in the cases that would benefit from treatment. This paper provides a summary of the current literature on the use of biochemical markers in predicting spontaneous preterm birth in symptomatic and high risk-asymptomatic women. Evidence from the literature suggests cervico vaginal fetal fibronectin,interleukin-6, phosphorylated Insulin-like growth factor binding protein-1(phIGFBP1), placental alpha macroglobulin-1 (PAMG-1) and serum
生化指标作为早产的预测指标——其临床意义和现状
早产与显著的围产期发病率和死亡率有关。自然早产占所有早产的75%。许多母亲和胎儿的特征都与早产有关。随着对早产病理生理学的深入了解,人们对各种生化指标进行了广泛的研究,以有效地预测早产,从而在需要治疗的情况下进行适当和及时的干预。本文综述了目前关于使用生化标志物预测有症状和高风险无症状妇女自发性早产的文献。文献证据表明,宫颈阴道胎儿纤维连接蛋白、白介素-6、磷酸化胰岛素样生长因子结合蛋白-1(phIGFBP1)、胎盘α -巨球蛋白-1(PAMG-1)和血清
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