Relationship between Blood Lipids, Lipoproteins and Ischemic Stroke

Bangladesh Journal of Neuroscience Pub Date : 2014-07-31 DOI:10.3329/bjn.v30i2.57393

Md Rezaul Karim Khan, A. Anwarullah, Md Shafiqus Saleheen, Sk. Mahbub Alam, Md. Rafiqul Islam, S. T. Alam

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引用次数: 2

Abstract

Objective: To find out the relationship of different lipids, lipoproteins and ischemic stroke patients in Bangladesh. Methodology: This case control study was conducted among the patients having ischemic stroke who were admitted in Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from July, 1997 to June, 1999 and age, sex matched apparently healthy volunteers. Sixty ischemic stroke patients confirmed by CT scan of brain and sixty age and sex matched apparently healthy volunteers were enrolled as controls. 12 hours fasting lipid profile (Total cholesterol, LDL-cholesterol, HDLcholesterol and Triglyceride) was done for both ischemic stroke patients and healthy volunteers for comparison. The students (unpaired) t test was used to compare group means for lipids and lipoproteins. Chi square test, odds ratio with confidence interval were done to evaluate differences between the groups for other variables. P<0.05 was considered as minimum level of significance. Result: The mean age (±SD) of the patients and controls were 58.45±10.12 and 59.40±10.41 years respectively and 44 (73.3%) were male and 16 (26.7%) were female and male- female ratio was 2.75:1 in both cases and controls. Total cholesterol (Means) was 201.62±5.52 mg/dl and 169.13±3.49 mg/dl in cases and controls respectively (P<0.001). HDL cholesterol (Means) was 38.36±0.81 mg/dl and 44.03±0.84 mg/dl in cases and controls respectively (P<0.001). LDL cholesterol (Mean±SE) in ischemic stroke patients and controls were 125.45±4.63 mg/dl and 96.40±3.23 mg/dl respectively (P<0.001). Triglyceride (Mean±SE) in cases and controls were 188.50±9.35 mg/dl and 142.85±4.72 mg/dl respectively (P<0.001). Conclusion: This case-control study showed significant differences of serum lipids and lipoproteins (Total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride) in ischemic stroke patients than the controls in our community. Bangladesh Journal of Neuroscience 2014; Vol. 30 (2): 96-103

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血脂、脂蛋白与缺血性脑卒中的关系

目的:了解孟加拉国不同血脂、脂蛋白与缺血性脑卒中患者的关系。方法:选取1997年7月至1999年6月在孟加拉国达卡班班杜谢赫·穆吉布医科大学神经内科住院的缺血性脑卒中患者为病例对照研究对象，这些患者均为年龄、性别明显健康的志愿者。60例脑CT确诊的缺血性脑卒中患者和60例年龄和性别明显匹配的健康志愿者作为对照。对缺血性脑卒中患者和健康志愿者进行12小时空腹血脂分析(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯)以进行比较。使用学生(未配对)t检验比较脂质和脂蛋白的组均值。其他变量采用卡方检验、优势比和置信区间评价组间差异。P<0.05为最低显著性水平。结果:患者和对照组的平均年龄(±SD)分别为58.45±10.12岁和59.40±10.41岁，其中男性44人(73.3%)，女性16人(26.7%)，男女比例为2.75:1。总胆固醇(平均值)分别为201.62±5.52 mg/dl和169.13±3.49 mg/dl (P<0.001)。高密度脂蛋白胆固醇(平均值)分别为38.36±0.81 mg/dl和44.03±0.84 mg/dl (P<0.001)。缺血性脑卒中患者LDL胆固醇(Mean±SE)为125.45±4.63 mg/dl，对照组为96.40±3.23 mg/dl (P<0.001)。甘油三酯(Mean±SE)分别为188.50±9.35 mg/dl和142.85±4.72 mg/dl (P<0.001)。结论:本病例对照研究显示，本区缺血性脑卒中患者血脂和脂蛋白(总胆固醇、HDL胆固醇、LDL胆固醇和甘油三酯)与对照组相比存在显著差异。孟加拉国神经科学杂志2014;Vol. 30 (2): 96-103

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Bangladesh Journal of Neuroscience

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