B. B. Legba, V. Dougnon, J. Agbankpe, K. Fabiyi, Christelle Lougbegnon, A. Soha, Césaire Ayena, E. Déguénon, H. Koudokpon, L. Baba-Moussa
{"title":"Assessment of Anti-Salmonella Activity of Aqueous and Ethanolic Extract of Senna siamae, Used in Traditional Management of Salmonellosis in Benin","authors":"B. B. Legba, V. Dougnon, J. Agbankpe, K. Fabiyi, Christelle Lougbegnon, A. Soha, Césaire Ayena, E. Déguénon, H. Koudokpon, L. Baba-Moussa","doi":"10.4236/PP.2020.119020","DOIUrl":null,"url":null,"abstract":"Recent ethnopharmacological data cited Senna siamea as one of the most widely used medicinal plants in the \nmanagement of salmonellosis in Benin. However, data related to its activity on non-typhoidal Salmonella spp are limited. \nThis study aimed to assess the antibacterial activity of Senna siamea on multidrug-resistant Salmonella. Ethanolic and aqueous extracts of S. siamea were tested for their antibacterial activity on four \nmultidrug-resistant Salmonella: Salmonella Typhimurium ATCC 14028 and \nthree Salmonella spp. isolated \nfrom animals intended for human consumption in Benin. Well diffusion technique \ncombined with the determination by microdilution of Minimum Bactericidal \nConcentration (MBC) and Minimum Inhibitory Concentration (MIC) were used for \nantibacterial testing. From antibacterial testing, inhibition diameters of the \nextracts ranged from 7 to 11 mm, for \nthe susceptible strains. Colistin (reference antibiotic) was active on all Salmonella spp. with inhibition \ndiameters between 18 and 19 mm. The MICs ranged from 3.125 to 25 mg/ml while \nMBCs of the extracts are greater than 100 mg/ml, so none of the extracts have \nantibacterial power (p.a). From these results, it appears that the use of Senna siamea in the \ntraditional treatment of salmonellosis is justified. These results must be \nvalued in the development of anti-salmonella phytomedicines.","PeriodicalId":19875,"journal":{"name":"Pharmacology & Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacology & Pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/PP.2020.119020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Recent ethnopharmacological data cited Senna siamea as one of the most widely used medicinal plants in the
management of salmonellosis in Benin. However, data related to its activity on non-typhoidal Salmonella spp are limited.
This study aimed to assess the antibacterial activity of Senna siamea on multidrug-resistant Salmonella. Ethanolic and aqueous extracts of S. siamea were tested for their antibacterial activity on four
multidrug-resistant Salmonella: Salmonella Typhimurium ATCC 14028 and
three Salmonella spp. isolated
from animals intended for human consumption in Benin. Well diffusion technique
combined with the determination by microdilution of Minimum Bactericidal
Concentration (MBC) and Minimum Inhibitory Concentration (MIC) were used for
antibacterial testing. From antibacterial testing, inhibition diameters of the
extracts ranged from 7 to 11 mm, for
the susceptible strains. Colistin (reference antibiotic) was active on all Salmonella spp. with inhibition
diameters between 18 and 19 mm. The MICs ranged from 3.125 to 25 mg/ml while
MBCs of the extracts are greater than 100 mg/ml, so none of the extracts have
antibacterial power (p.a). From these results, it appears that the use of Senna siamea in the
traditional treatment of salmonellosis is justified. These results must be
valued in the development of anti-salmonella phytomedicines.