Assessment of Anti-Salmonella Activity of Aqueous and Ethanolic Extract of Senna siamae, Used in Traditional Management of Salmonellosis in Benin

B. B. Legba, V. Dougnon, J. Agbankpe, K. Fabiyi, Christelle Lougbegnon, A. Soha, Césaire Ayena, E. Déguénon, H. Koudokpon, L. Baba-Moussa
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引用次数: 1

Abstract

Recent ethnopharmacological data cited Senna siamea as one of the most widely used medicinal plants in the management of salmonellosis in Benin. However, data related to its activity on non-typhoidal Salmonella spp are limited. This study aimed to assess the antibacterial activity of Senna siamea on multidrug-resistant Salmonella. Ethanolic and aqueous extracts of S. siamea were tested for their antibacterial activity on four multidrug-resistant Salmonella: Salmonella Typhimurium ATCC 14028 and three Salmonella spp. isolated from animals intended for human consumption in Benin. Well diffusion technique combined with the determination by microdilution of Minimum Bactericidal Concentration (MBC) and Minimum Inhibitory Concentration (MIC) were used for antibacterial testing. From antibacterial testing, inhibition diameters of the extracts ranged from 7 to 11 mm, for the susceptible strains. Colistin (reference antibiotic) was active on all Salmonella spp. with inhibition diameters between 18 and 19 mm. The MICs ranged from 3.125 to 25 mg/ml while MBCs of the extracts are greater than 100 mg/ml, so none of the extracts have antibacterial power (p.a). From these results, it appears that the use of Senna siamea in the traditional treatment of salmonellosis is justified. These results must be valued in the development of anti-salmonella phytomedicines.
在贝宁沙门氏菌病传统治理中使用的番泻水提物和乙醇提物抗沙门氏菌活性评价
最近的民族药理学数据指出,塞纳是贝宁沙门氏菌病管理中使用最广泛的药用植物之一。然而,有关其对非伤寒沙门氏菌活性的数据有限。本研究旨在评价番泻草对耐多药沙门氏菌的抑菌活性。本文对四种多重耐药沙门氏菌(鼠伤寒沙门氏菌ATCC 14028)和三种从贝宁供人食用动物中分离的沙门氏菌)的乙醇提取物和水提取物进行了抑菌活性测试。采用孔扩散法结合微量稀释法测定最小杀菌浓度(MBC)和最小抑菌浓度(MIC)进行抑菌试验。抑菌试验结果表明,提取物对敏感菌的抑菌直径为7 ~ 11 mm。粘菌素(参比抗生素)对所有沙门氏菌均有抑制作用,抑制直径在18 ~ 19 mm之间。mic值为3.125 ~ 25 mg/ml,而MBCs值均大于100 mg/ml,均不具有抑菌力(p.a)。从这些结果来看,在沙门氏菌病的传统治疗中使用番泻是合理的。这些结果在开发抗沙门氏菌植物药时必须加以重视。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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