Controlled release of DEET and Picaridin mosquito repellents from microcapsules prepared by complex coacervation using gum Arabic and chitosan

Q4 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI:10.29090/psa.2022.05.22.110

Worn Donchai, A. K. Aldred, A. Junkum, A. Chansang

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Abstract

Microcapsules (MCs) of mosquito repellents (DEET and Picaridin) were prepared by complex coacervation using gum Arabic and chitosan as wall materials. The resulting diameters of MCs were 2.35±0.76 µm for DEET and 4.26±1.77 µm for Picaridin, analyzed by optical microscopy. Spherical mononuclear-type MCs were also observed. The mean particle size of dried DEET-MC and Picaridin-MC was 182 µm and 140 µm, respectively, indicating agglomeration of MCs. Fourier transform infrared spectroscopy confirmed the encapsulation of repellents by the appearance of carbonyl (C=O) absorption bands in the associated spectra. Moreover, the microencapsulation efficiency was 60% and 73% for DEET and Picaridin, respectively, determined by Soxhlet extraction. From Thermogravimetric analysis, delay of DEET and Picaridin losses revealed encapsulation of DEET and Picaridin inside the MCs. In addition, the higher release rate of Picaridin compared to DEET under isothermal conditions was correlated with longer protective time relative to the free repellents, as demonstrated by the “arm in cage” test. The study concludes that microencapsulated DEET and Picaridin show high promise of functional textiles for mosquito repellency.

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阿拉伯胶和壳聚糖复合凝聚法制备避蚊胺和皮卡瑞丁驱蚊剂微胶囊的控释研究

以阿拉伯胶和壳聚糖为壁材，采用复合凝聚法制备了避蚊胺和异蚊定驱蚊剂微胶囊。经光学显微镜分析，避蚊胺的MCs直径为2.35±0.76µm，吡啶的MCs直径为4.26±1.77µm。还观察到球形单核型MCs。干燥后避蚊胺- mct和皮卡瑞丁- mct的平均粒径分别为182µm和140µm，表明MCs存在团聚现象。傅里叶变换红外光谱通过相关光谱中羰基(C=O)吸收带的出现证实了驱蚊剂的包封性。索氏提取法测定避蚊胺和皮卡瑞定的微胶囊化率分别为60%和73%。从热重分析来看，避蚊胺和皮卡瑞丁的延迟损失表明避蚊胺和皮卡瑞丁被包裹在MCs内。此外，在等温条件下，与避蚊胺相比，皮卡瑞丁释放率更高，与游离驱蚊剂相比，保护时间更长，这一点在“笼中手臂”试验中得到了证实。研究表明，微胶囊化避蚊胺和吡啶虫胺是一种很有前景的功能性驱蚊纺织品。

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来源期刊

Pharmaceutical Sciences Asia Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Pharmaceutical Sciences Asia (PSA) journal is a double-blinded peer-reviewed journal in English published quarterly, by the Faculty of Pharmacy, Mahidol University, Thailand. The PSA journal is formerly known as Mahidol University Journal of Pharmaceutical Sciences and committed to the timely publication of innovative articles and reviews. This journal is available in both printed and electronic formats. The PSA journal aims at establishing a publishing house that is open to all. It aims to disseminate knowledge; provide a learned reference in the field; and establish channels of communication between academic and research expert, policy makers and executives in industry and investment institutions. The journal publishes research articles, review articles, and scientific commentaries on all aspects of the pharmaceutical sciences and multidisciplinary field in health professions and medicine. More specifically, the journal publishes research on all areas of pharmaceutical sciences and related disciplines: Clinical Pharmacy Drug Synthesis and Discovery Targeted-Drug Delivery Pharmaceutics Biopharmaceutical Sciences Phytopharmaceutical Sciences Pharmacology and Toxicology Pharmaceutical Chemistry Nutraceuticals and Functional Foods Natural Products Social, Economic, and Administrative Pharmacy Clinical Drug Evaluation and Drug Policy Making Antimicrobials, Resistance and Infection Control Pharmacokinetics and Pharmacodynamics.