Gastrointestinal Stromal Tumors

Abstract

Gastrointestinal stromal tumors(GIST) is a kind of tumor which originated from gastrointestinal submucosa,of which the molecular biological mechanism is the mutation of proto-oncogene c-kit.Its clinical characteristics is that it can occur in the whole gastrointestinal tract,especily in stomach as well as lack of specific clinical manifestation.Imaging examination has high value in judging morphology questions including its biological behavior,structural feature and so on.Its immunohistochemistry almost shows positive CD34、CD117.Its diagnosis depends on combined application of clinical manifestation,imaging changes,pathological morphology and immunohistochemistry.Surgery is the main therapeutic method although there are great breakthrough in its molecular targeted therapy.