An overview of the risk, underlying factors, and mechanism of cancer progression in polycystic ovary syndrome

Tumor discovery Pub Date : 2023-03-17 DOI:10.36922/td.328

Rubiat Afrin Ayon, Md. Azmain Faike, Sumiya Zaman Ononna, Aminul Hassan, Shoumik Kundu, Farhana Akhter, Mohammad Mahfuz Ali Khan Shawan, Md. Mozammel Hossain, Md. Ibrahim Khalil, Md. Ashraful Hasan

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Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder among women of reproductive age. PCOS is characterized by ovulatory dysfunction, clinical or biochemical features of hyperandrogenism, and polycystic ovaries. The risk of cancer among PCOS patients has been a topic of discussion for decades due to the overlapping metabolic and endocrine abnormalities. This review article focuses on the association of PCOS with various types of reproductive (such as endometrial cancer, ovarian cancer, and breast cancer) and non-reproductive cancers, considering different aspects, such as the risk of cancer progression in PCOS patients, the underlying factors, and the mechanism through which PCOS might progress to cancer. The information provided in this article would help create awareness among PCOS patients about the need to take risk-reducing measures. This article might also aid in the effort of identifying novel therapeutic targets to counteract the progression of cancer in PCOS.

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多囊卵巢综合征癌症进展的风险、潜在因素和机制综述

多囊卵巢综合征(PCOS)是育龄妇女最常见的内分泌代谢疾病。多囊卵巢综合征以排卵功能障碍、高雄激素血症和多囊卵巢为临床或生化特征。由于多囊卵巢综合征患者的代谢和内分泌异常重叠，其癌症风险一直是几十年来讨论的话题。本文就多囊卵巢综合征(PCOS)与各种类型的生殖(如子宫内膜癌、卵巢癌、乳腺癌)和非生殖癌症的关系进行综述，从多囊卵巢综合征患者的癌症进展风险、潜在因素以及多囊卵巢综合征发展为癌症的机制等方面进行探讨。本文提供的信息将有助于提高多囊卵巢综合征患者对采取降低风险措施的必要性的认识。这篇文章也可能有助于发现新的治疗靶点来对抗多囊卵巢综合征的癌症进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tumor discovery

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