Improved Coronary Sinus Blood Sampling for Cardiac Research

Journal of Clinical and Experimental Cardiology Pub Date : 2018-02-02 DOI:10.4172/2155-9880.1000568

S. Dawkins, M. Alkhalil, G. L. Maria, G. Fahrni, G. Kassimis, Regent Lee, N. Patel, A. Banning, R. Choudhury, C. Forfar, R. Kharbanda, J. Langrish, A. Lucking, K. Channon

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Abstract

Background: Coronary sinus (CS) blood sampling is important for measuring metabolites and biomarkers in cardiovascular research, but can be technically challenging. Here we demonstrate the use of the antecubital fossa for CS blood sampling as an alternative to femoral access, and a simple technique of paired venous and CS blood gas analysis for confirmation of valid CS sampling. We also demonstrate improvement in sampling accuracy by using a coronary guide wire to stabilize the sampling catheter in the CS. Methods: Paired blood samples from CS and peripheral vein were collected from patients at the time of primary PCI for acute myocardial infarction. Venous access for CS sampling was via the antecubital vein. Blood gas analysis was used to confirm a true CS sample (pO2[CS]

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改良冠状窦血液取样心脏研究

背景:冠状窦(CS)血液采样对于测量心血管研究中的代谢物和生物标志物非常重要，但在技术上具有挑战性。在这里，我们展示了使用前窝进行CS血液采样作为股骨通道的替代方法，以及一种简单的配对静脉和CS血气分析技术，以确认有效的CS采样。我们还演示了通过使用冠状动脉导丝来稳定CS中的采样导管来提高采样精度。方法:对急性心肌梗死患者首次行PCI时的CS和外周静脉配对采血。CS取样的静脉通路是通过肘前静脉。血气分析证实为真CS (pO2[CS]

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Journal of Clinical and Experimental Cardiology

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