Effect of two levels of olive leaf and doum powder and their mixture in female rats suffering from acute nephritis using CCL4

Abstract

37 Abstract Olive leaves and doum are two of several herbal medicines that are used either as food or adrink.This study was designed to explore the potential protective effect of doum, olive leaves and a mixture of them using percentages (4% and 8%) during infecting female rats With acute kidney injury using carbon tetrachloride with paraffin oil ( v/v 1ml/kg of body weight) three-time/week for 4 weeks, where the duration of the experiment was 5 weeks, one week of them was to rehabilitate the rat. The rats weighing an average of (190±10) forty of rats were divided into eight groups (n=5 rats). G 1 was fed on the basal diet and kept as a negative control group.The other 7 groups were injectedintraperitoneally with CCL 4 and paraffin oil( v/v) 1ml/kg of body weight)three time/week for 4 weeksto induce acute damage in the kidney.G2 was fed on a basal diet and left as a positive control group and group (3 and 4),(5 and 6) and (7 and 8) were fed on supplemented diet with( 4% and 8%) olive leaves,doum and mixture of them,respectively.The obtained results revealed that the treating groups with olive leaves,doum and a mixture of them had significantly reduced serum levels of (lipid profile, except HDL-c ) andkidney functions,liver enzymes, while these treatments induced no significant in feed intake (FI),body weight gain(BWG),feed efficiency ratio (FER) and a significant increase in serum levels of HDL-c,glutathioneperoxidase(GPX),superoxide dismutase (SOD) and catalase (CAT) enzymes ,as well as partially improvements in kidneys structures compared to those of positive control group.The best improvements in all the biochemical parameters and histological structures of the liver and kidneys which were tended toward normal results were observed in protective groups(7&8).