{"title":"The Transplantation of Human Pluripotent Stem Cells is Safe: A Personal Experience during the Past 5 Years (I)","authors":"Taihua Wang, Xiaohui Cui, Zhenzhen Yang, Linyu Cui, Rongrong Li, Xinyi Shi, X. Jiang, Shufeng Du, Mengqian Wang, Guoke Yang, Ying Meng, Gang Zhang","doi":"10.33425/2639-9512.1068","DOIUrl":null,"url":null,"abstract":"The greatest dilemma of human pluripotent stem cell transplantation therapy clinically is the potential risk to form teratomas in the recipient’s body. On the one hand, to date, no data can confirm this risk. On the other hand, no data can confirm the safety of human pluripotent stem cell transplantations, either. To break this dilemma, the correspondence author, G Z, decided to accept human pluripotent stem cell transplantations voluntarily. During the past five years, G Z accepted totally 77 times human stem cell transplantations with/without overexpressing different human genes, and the whole number of human stem cells was up to approximately 6.36 X 109 . After medical examinations, the results demonstrated that G Z’s health conditions were basically normal. Thus, our investigations preliminarily proved that intravenous transplantations of human pluripotent stem cells were safe so far, at least for this case.","PeriodicalId":91668,"journal":{"name":"Cell, stem cells and regenerative medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell, stem cells and regenerative medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33425/2639-9512.1068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The greatest dilemma of human pluripotent stem cell transplantation therapy clinically is the potential risk to form teratomas in the recipient’s body. On the one hand, to date, no data can confirm this risk. On the other hand, no data can confirm the safety of human pluripotent stem cell transplantations, either. To break this dilemma, the correspondence author, G Z, decided to accept human pluripotent stem cell transplantations voluntarily. During the past five years, G Z accepted totally 77 times human stem cell transplantations with/without overexpressing different human genes, and the whole number of human stem cells was up to approximately 6.36 X 109 . After medical examinations, the results demonstrated that G Z’s health conditions were basically normal. Thus, our investigations preliminarily proved that intravenous transplantations of human pluripotent stem cells were safe so far, at least for this case.
临床应用人类多能干细胞移植治疗的最大难题是在受者体内形成畸胎瘤的潜在风险。一方面，到目前为止，没有数据可以证实这种风险。另一方面，也没有数据可以证实人类多能干细胞移植的安全性。为了打破这种困境，通信作者gz决定自愿接受人类多能干细胞移植。在过去的五年中，gz共接受了77次有/没有过表达不同人类基因的人类干细胞移植，人类干细胞总数约为6.36 X 109。经医学检查，gz的健康状况基本正常。因此，我们的研究初步证明，到目前为止，静脉内移植人类多能干细胞是安全的，至少对这个病例来说是安全的。
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