Relationship between the changes of plasma levels of leptin and obesity in patients with insulinoma

中华消化杂志 Pub Date : 2019-08-15 DOI:10.3760/CMA.J.ISSN.0254-1432.2019.08.010

Shuang Yu, Hai‐yan Wu, Ming Li, Qiang Wang, Li-ming Zhu, Yuan-jia Chen

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Abstract

Objective To analyze the relationship between the changes of fasting plasma level of leptin and obesity in patients with insulinoma before operation. Methods From January 2003 to May 2008, 40 patients with insulinoma diagnosed at Peking Union Medical College Hospital were selected. Preoperative fasting plasma samples of them were collected. From January 2003 to May 2008, the plasma samples of 28 volunteers matched with age, gender and body weight matched with the patients were collected as the controls. All the subjects were divided into overweight-obesity group and normal weight group according to their body mass index (BMI). Plasma levels of leptin of all the subjects were measured by enzyme linked immunosorbent assay(ELISA). The Mann-Whitney U test and the correlation coefficient test were used for statistical analysis. Results The plasma leptin level of patients with insulinoma was 0.35 ng/mL (0.25 ng/mL to 1.13 ng/mL), which was higher than that of the control group (0.29 ng/mL, 0.25 ng/mL to 1.15 ng/mL), and the difference was statistically significant (U=324.50, P=0.003). In the normal-weight group, the plasma leptin level of the patients with insulinoma was 0.35 ng/mL (0.27 ng/mL to 0.62 ng/mL), which was higher than that of the control group (0.28 ng/mL, 0.25 ng/mL to 0.37 ng/mL), and the difference was statistically significant (U=28.000, P=0.001). While in the overweight-obesity group, the plasma leptin levels of the patients with insulinoma and the controls were 0.35 ng/mL (0.25 ng/mL to 1.13 ng/mL) and 0.34 ng/mL (0.26 ng/mL to 1.15 ng/mL), respectively, and the difference was not statistically significant (U=153.500, P=0.525). Plasma leptin levels in both the patients with insulinoma and the controls, were correlated with BMI (r=0.355, P=0.025; r=0.571, P=0.001, respectively). Conclusion Preoperative fasting plasma level of leptin increase in patients with insulinoma which is correlated with BMI. Key words: Insulinoma; Obesity; Leptin; Insulin; Body mass index; Pancreatic neuroendocrine tumor

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胰岛素瘤患者血浆瘦素水平变化与肥胖的关系

目的分析胰岛素瘤术前空腹血浆瘦素水平变化与肥胖的关系。方法选择2003年1月~ 2008年5月在北京协和医院确诊的胰岛素瘤患者40例。采集术前空腹血浆样本。从2003年1月至2008年5月，收集年龄、性别、体重与患者相匹配的28名志愿者的血浆样本作为对照。根据体重指数(BMI)将所有受试者分为超重肥胖组和正常体重组。采用酶联免疫吸附试验(ELISA)测定所有受试者血浆瘦素水平。采用Mann-Whitney U检验和相关系数检验进行统计分析。结果胰岛素瘤患者血浆瘦素水平为0.35 ng/mL (0.25 ng/mL ~ 1.13 ng/mL)，高于对照组(0.29 ng/mL、0.25 ng/mL ~ 1.15 ng/mL)，差异有统计学意义(U=324.50, P=0.003)。正常体重组胰岛素瘤患者血浆瘦素水平为0.35 ng/mL (0.27 ng/mL ~ 0.62 ng/mL)，高于对照组(0.28 ng/mL、0.25 ng/mL ~ 0.37 ng/mL)，差异有统计学意义(U=28.000, P=0.001)。而在超重肥胖组，胰岛素瘤患者与对照组血浆瘦素水平分别为0.35 ng/mL (0.25 ng/mL ~ 1.13 ng/mL)和0.34 ng/mL (0.26 ng/mL ~ 1.15 ng/mL)，差异无统计学意义(U=153.500, P=0.525)。胰岛素瘤患者和对照组血浆瘦素水平均与BMI相关(r=0.355, P=0.025;r=0.571, P=0.001)。结论胰岛素瘤患者术前空腹血浆瘦素水平升高与BMI相关。关键词:胰岛素瘤;肥胖;瘦素;胰岛素;身体质量指数;胰腺神经内分泌肿瘤

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中华消化杂志

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