Aldehydes and Ketones as Dipolarophiles. Application to the Synthesis of Oxapenams

Andrews, Giles A. Brown, J. Charmant, T. Peakman, Arlene Rebello, K. E. Walsh, T. Gallagher, N. Hales
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引用次数: 12

Abstract

2-Substituted (6a–e) and 2, 2-disubstituted oxapenams (6f–g) are obtained in one step by thermolysis of the β-lactam-based oxazolidinone 4 in the presence of aldehydes and reactive ketones respectively; the C(6)-substituted oxazolidinone variant 7 reacts with hexafluoroacetone to give the enantiomerically pure oxapenam 8.
醛类和酮类作为亲偶极试剂。在奥沙培南合成中的应用
2-取代(6a-e)和2,2 -二取代奥沙巴南(6f-g)分别由β-内酰胺基恶唑烷酮4在醛和活性酮存在下一步热解得到;C(6)取代的恶唑烷酮变体7与六氟丙酮反应得到对映体纯的奥沙那南8。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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