Designing a Wavelength-Swept Raman Spectroscopy System for Optical Guidance Neurosurgery

Abstract

Raman spectroscopy has been used for disease diagnosis in cancer research and brain research. The purpose of the present paper is to show a proof-of-concept for a swept-source setup for real-time in vivo Raman spectroscopy at high speed with high signal to noise ratio. The obtained Raman spectrum could be used to differentiate brain regions such as white and grey matter, providing guidance information during deep brain stimulation neurosurgery to treat Parkinson disease.