Pathogenic bacteria of diabetic-associated infections and their pathogenesis

Abstract

ISSN The diabetic patients have tendencies to develop infections in presence of hyperglycemia makes mucosal epithelial more susceptible to infections. Diabetic mellitus causes a sever deregulation of immune response in a healthy human body. The suppressed production of immune pepetides and altered immune, susceptibility to infections are much higher in immunosuppressed patients with diabetes mellitus. The human host and microorganisms normally exist in a balanced relationship. Infection occurs when pathogens are able to resist host’s immune system and subsequently invade systemic host responses. The reasons why infections do not recover are related to local factors associated with the infections and also with comorbidities such as diabetes. In this review, we discuss the influence of diabetes in bacterial infection and their mechanism emphasizing their role in bacterial pathogensis. Copyright 2020 Wolters Kluwer Health, Inc. All rights reserved.