Histological features of the structure of the portal vein of the liver and splenic vein in portal hypertension

Abstract

Aim - histological study of the structure and thickness of the membranes of the portal vein of the liver and splenic vein in people of different age groups in normal conditions and with portal hypertension. Materials and methods. Sectional material for the study of the portal vein of the liver and splenic vein was obtained from 89 people aged 7 to 30 years who died from injuries incompatible with life. In 57 cases during life, patients had a history of portal hypertension, the remaining 32 cases were considered as controls. Cellular and tissue components of the vein walls were studied on paraffin sections stained with hematoxylin-eosin, as well as according to Van Gieson using Weigert's hematoxylin, picric acid, and fuchsin. Results. It was found that in case of portal hypertension, in comparison with the control, the thickness of the inner and middle membranes of venous vessels significantly increased in all age groups. Pathological features of changes in the thickness and microstructure of the components of the portal vein wall of the liver and splenic vein in topographically different parts of the veins are shown. Conclusions. Pathological changes in the wall of the portal vein of the liver and splenic vein in portal hypertension are pronounced and regular in both young people and children and adolescents, which is an urgent problem for clinical practice. Further study of the structures of GDP and SW will help to form representations of the average stress parameters, the digital values of which have a different range in relation to the norm.