STUDY OF VARIABILITY IN THE ACTIVITY OF RIBOSOMAL CISTRONES IN COLORECTAL CANCER

Abstract

According to the World Health Organization, colon cancer is one of the most common cancers. By 2020, approximately 1,900,000 cases of CRC were detected worldwide (a total of 10%). In 2020, American Cancer Society 104,610 new cases of CRC were identified and 53,200 patients died. Similar to other tumors colon cancer (CRC) is a genetically inherited multifactorial disease. It is established that genetic, immunologic, as well as environmental factors, all play significant role in CRC development and metastasis. As mentioned, carcinogenesis is associated with the whole number of genetic phenomena ongoing in certain groups of the genes; it is of staged nature and includes interactions of gene suppressors and oncogenes. Many genes responsible for CRC development were identified, family forms were described as well. In particular, high risk of CRC development in case of family history of adenomatous polyposis was demonstrated. As mentioned, neoplastic variability of the tumors is associated with changed morphogenesis of the nucleus, in turn, playing certain role in regulation of the suppressor genes p53, APC and pro-carcinogenesis KRAS.