Express method for determining the sensitivity of pathogens of bacterial complications in COVID-19 to bacteriophages

L. Kraeva, Lidiya Sergeevna Konkova, Olga Alexandrovna Burgasova, S. Dolinny
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Abstract

In recent years, there has been a catastrophic increase in the resistance of bacterial strains to antibacterial drugs. The spread of the pandemic of the new coronavirus infection COVID-19 has led to excessive use of antibiotics, which has caused an even wider spread of resistant strains in hospitals. Taking into account the accumulated positive experience of using bacteriophages, it is advisable to use them for the treatment of patients after determining the sensitivity of each strain of isolated bacteria to bacteriophages. Since, according to numerous sources, Klebsiella pneumoniae bacteria were most often isolated in complicated forms of COVID-19, it became necessary to quickly determine the sensitivity of these and other gram-negative bacteria to the corresponding bacteriophages. The developed express method for determining the sensitivity of gram-negative bacteria to bacteriophages makes it possible to reduce the study time by 6 times, namely up to 3 hours. This will significantly reduce the timing of the selection of etiotropic therapy in the form of bacteriophages for individual therapy of patients.
快速测定COVID-19细菌性并发症病原菌对噬菌体敏感性的方法
近年来,细菌菌株对抗菌药物的耐药性出现了灾难性的增长。新型冠状病毒感染COVID-19大流行的传播导致抗生素的过度使用,从而导致耐药菌株在医院更广泛地传播。考虑到积累的使用噬菌体的积极经验,在确定每株分离细菌对噬菌体的敏感性后,建议将其用于患者的治疗。根据众多消息来源,肺炎克雷伯菌最常在复杂形式的COVID-19中分离出来,因此有必要快速确定这些细菌和其他革兰氏阴性细菌对相应噬菌体的敏感性。所开发的测定革兰氏阴性菌对噬菌体敏感性的快速方法使研究时间缩短了6倍,即最多3小时。这将大大减少选择以噬菌体形式对患者进行个体化治疗的致病因治疗的时间。
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