An update on the recovery of [18O]water during the synthesis of [18F]FDG by a simple modification in the procedure

Abstract

A simple procedural change for the synthesis of [¹⁸F]FDG has been used to recover [¹⁸O]water by direct distillation. The [¹⁸O]water thus recovered is reusable to produce [¹⁸F]fluoride without further purification. The recovery of [¹⁸O]water is reliable and our results are based on over 300 routine FDG preparations. The [¹⁸F]fluoride present in the target water is converted to potassium fluoride during the distillation and will be available for further reaction to complete the synthesis of FDG. The same procedure can be used to recover [¹⁸O]water in similar situations where [¹⁸F]fluoride is converted to potassium fluoride and in turn used to react with kryptofix for labeling other precursors.