The role of dynamic and diffusion weighted magnetic resonance imaging in differentiating malignant and benign portal vein thrombosis

Abstract

Aim: The aim of this study was to evaluate the role of dynamic and diffusion-weighted (DW) magnetic resonance imaging (MRI) in the differentiation of benign from malignant thrombus in patients diagnosed with portal vein thrombosis. Material and Methods: The test results of a total of 56 patients were analyzed in this study, of which 27 with benign and 29 with malignant thrombus on abdomen dynamic and DW-MRI. The b-value of DW-MRI was 400 and 1,000 mm2/sec. ADC of portal vein thrombosis was measured. Characteristics of the DW-MRI signal were recorded. Contrast imaging of the thrombus was performed. The diameter of the portal vein was measured. A comparison of the ADC values between the malignant and benign groups was made using the Mann-Whitney U test. Results: The mean ADC values of benign thrombus were calculated as 1.03±0.27 x 10-3 mm2/sec for b400, and 1.01±0.23 x 10-3 mm2/sec for b1000. The mean ADC values were calculated as 0.93±0.13 x 10-3 mm2/sec for b400 and 0.88±0.26 x 10-3 mm2/sec for b1000 for malignant thrombus. No statistically significant difference was found between the groups (p=0.778). Malignant thrombus was reported to have higher signal intensity compared to the benign cases in DW-MRI. Arterial mild contrasting was found with malignant thrombus with dynamic MRI on subtraction images. Contrast media uptake was not seen in the benign group. Statistically significant difference was found between the groups for portal vein diameter (p