The roles of cell cycle and BRCA1 in the DNA damage response

Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response Pub Date : 2021-01-29 DOI:10.3390/iecc2021-09193

Shihori Tanabe, S. Quader, R. Ono, H. Cabral, K. Aoyagi, A. Hirose, H. Yokozaki, H. Sasaki

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Abstract

Molecular network activation states alter dynamically in biology and diseases. In cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT) networks play an important role to acquisition of the drug resistance and cancer malignant feature. To reveal the network pathways in EMT and CSCs, gene expression in diffuse- and intestinal-type gastric cancer (GC) have been analyzed. The several canonical pathways have been found to be altered in diffuse- and intestinal-type GC. Canonical pathway on Cell Cycle: G1/S Checkpoint Regulation was activated in diffuse-type GC, and Cyclins and Cell Cycle Regulation was activated in intestinal-type GC. In Cell Cycle: G1/S Checkpoint Regulation, DNA damage induces p53, which was predicted to be activated in diffuse-type GC. Canonical pathway related to Role of BRCA1 in DNA Damage Response was activated in intestinal-type GC, where BRCA1 which is related to G1/S phase transition was up-regulated. Cell cycle regulation may be altered in EMT condition in diffuse-type GC.

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细胞周期和BRCA1在DNA损伤反应中的作用

分子网络激活状态在生物学和疾病中是动态变化的。在肿瘤干细胞(CSCs)中，上皮-间质转化(EMT)网络在耐药和肿瘤恶性特征的获得中起着重要作用。为了揭示EMT和CSCs的网络通路，我们分析了弥漫型和肠型胃癌(GC)中的基因表达。已经发现弥漫性和肠型GC的几个典型途径发生了改变。细胞周期的典型途径:弥漫性GC激活G1/S检查点调节，肠型GC激活Cyclins和细胞周期调节。在细胞周期:G1/S检查点调节中，DNA损伤诱导p53，预计在弥漫性GC中p53被激活。在肠型GC中，与BRCA1在DNA损伤反应中作用相关的典型通路被激活，与G1/S相变相关的BRCA1上调。弥漫性GC在EMT条件下可能改变细胞周期调控。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response

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