In Silico Analysis of the FOXP3 Transcription Factor Associated with T-Cell Oncogenesis

Abstract

Background: The X chromosome encoded FOXP3 gene is a unique regulator of the T-cell differentiation and immunosuppressive function. The nuclear transcription factor FOXP3 gene regulates lineage-specific differentiation in the Treg crucially maintenance of the immune homeostasis. The regulatory T-cell (Treg or CD4+ cells) play a role in the immune response for self-antigens, allergens, and tumours. However, FOXP3 gene function is inconsistent in tumorigenesis such as tumour-suppressive and tumour-promoting. A recent report suggested the FOXP3 gene repress tumorigenesis per effects on proliferation and apoptosis. Objective: My objective was to investigate the FOXP3 gene from the FOX family in between Homo sapiens and Musmusculus. The study of the FOXP3 gene is currently mandatory to explore the molecular mechanisms of the Treg differentiation and immunosuppressive function in a particular organism. Methods: I perform bioinformatics and computational tools and technique to the current knowledge of the FOX family in the mammalian genome. My procedure may be useful for future functional analysis of specific gene family in particular organisms. Results: In this study, I conducted a compressive genome-wide survey of the FOX family in mammals. My findings documented the FOX family play an essential role during development. The functional regulation of the FOXP3 gene exhibits tumour suppressor activity. The specific structure, domain, motifs, phylogeny, gene expression, and chromosome locationanalysis suggested that the FOXP3 gene is a T-cell dependent gene. Conclusion: My analysis data concluded the FOX family plays a crucial role during development. In contrast, the restricted expression of the FOXP3 gene in the T-cell is an immune-privileged. The ultimate function of the FOXP3 gene in tumour cells may represent a novel mechanism in the immune system.