Identification of target genes of oncogenic transcription factors.

Kathryn E. Boyd, P. Farnham
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引用次数: 37

Abstract

Disregulation of many transcription factors is associated with the development of human neoplasia. Transcription factors regulate cell growth, differentiation, and apoptosis by binding to specific DNA sequences within the promoter regions of growth-regulatory genes and modulating expression of these genes. This simple model is complicated by the fact that mammalian transcription factors are often members of large protein families that bind to similar DNA sequences. This raises the question as to whether members of a particular family regulate expression of overlapping or unique sets of genes. This review is focused on addressing this question using the Ets, Myc, and E2F transcription factor families as examples. Deregulated activity of some, but not all, members of these families is observed in cancer. Here, we summarize the data illustrating the concept that binding of individual members of these families of factors can result in promoter-specific responses and review the studies that have provided some insight into how target gene specificity is achieved. Since, for all of these oncogenic transcription factors, it remains unclear exactly which target genes are important in neoplasia, we have also reviewed the many approaches researchers are using to identify target genes of the various Ets, Myc, and E2F family members.
致癌转录因子靶基因的鉴定。
许多转录因子的失调与人类肿瘤的发展有关。转录因子通过结合生长调节基因启动子区域内的特定DNA序列并调节这些基因的表达来调节细胞的生长、分化和凋亡。由于哺乳动物转录因子通常是结合相似DNA序列的大蛋白质家族的成员,这个简单的模型变得复杂了。这就提出了一个问题,即一个特定家族的成员是否调节重叠或独特的基因集的表达。本文以Ets、Myc和E2F转录因子家族为例,重点讨论了这一问题。在癌症中可以观察到这些家族成员的一些(但不是全部)不受管制的活动。在这里,我们总结了说明这些因子家族的个体成员的结合可以导致启动子特异性反应的概念的数据,并回顾了为如何实现靶基因特异性提供一些见解的研究。由于,对于所有这些致癌转录因子,目前尚不清楚哪些靶基因在肿瘤中起重要作用,我们也回顾了研究人员用于鉴定各种et、Myc和E2F家族成员靶基因的许多方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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