Diyabetli Hastalarda Miyokard Perfüzyon Sintigrafisinde Miyokard İskemisini Öngörmede Ürik Asit-HDL Kolesterol Oranının Rolü

Q4 Medicine
Hamdi Afşin
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Abstract

The Role of Uric Acid to HDL Cholesterol Ratio in Predicting Myocardial Ischemia in Myocardial Perfusion Scintigraphy in Diabetic Patients Abstract Objective: Diabetes Mellitus (DM) is a significant risk factor for cardiovascular diseases, particularly myocardial ischemia. Both diabetes mellitus type 2 and cardiovascular conditions are characterized by a high burden of inflammation. The uric Acid to High-Density Lipoprotein cholesterol ratio (UHR) has been suggested as a novel marker of metabolic and inflammatory diseases. Hence, this study investigated the predictive role of the Uric Acid to High-Density Lipoprotein cholesterol ratio (UHR) in myocardial ischemia detected by Myocardial Perfusion Scintigraphy (MPS) in diabetic patients. Materials and Methods: This study included patients who underwent MPS between January 2022 and March 2023 at the Nuclear Medicine Department of Abant Izzet Baysal University Hospital. Based on the MPS results, the participants were divided into normal perfusion and myocardial ischemia. Variables such as age, sex, leukocyte count, hemoglobin, hematocrit, platelet count, serum uric acid, urea, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, transaminase, blood fasting glucose, C-reactive protein, and serum albumin were recorded and compared between the groups. Results: Among the 73 diabetic patients, 37 had myocardial ischemia, and 36 had normal MPS. Serum uric acid levels were higher in the ischemic group (6.3 ± 1.5 mg/dL) than in the normal group (5.1 ± 1.8 mg/dL) (p
摘要目的:糖尿病(DM)是心血管疾病尤其是心肌缺血的重要危险因素。2型糖尿病和心血管疾病的特点是炎症负担高。尿酸与高密度脂蛋白胆固醇比值(UHR)已被认为是代谢性和炎症性疾病的新标志物。因此,本研究探讨了心肌灌注闪烁成像(MPS)检测尿酸与高密度脂蛋白胆固醇比值(UHR)对糖尿病患者心肌缺血的预测作用。材料和方法:本研究纳入了2022年1月至2023年3月在Abant Izzet Baysal大学医院核医学部接受MPS的患者。根据MPS结果将受试者分为正常灌注组和心肌缺血组。记录年龄、性别、白细胞计数、血红蛋白、红细胞压积、血小板计数、血清尿酸、尿素、肌酐、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、转氨酶、空腹血糖、c反应蛋白和血清白蛋白等变量,并比较各组之间的差异。结果:73例糖尿病患者中心肌缺血37例,MPS正常36例。缺血组血清尿酸水平(6.3±1.5 mg/dL)高于正常组(5.1±1.8 mg/dL) (p
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来源期刊
Duzce Medical Journal
Duzce Medical Journal Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
59
审稿时长
12 weeks
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