Evaluation of anti-epileptic activity of fresh fruit juice of Moringa oleifera against maximal electroshock (M.E.S) and Picrotoxin (PTX) induced convulsions in mice

Abstract

Moringa oleifera (Moringaecea) are used in Indian traditional medicine and in folklore for many diseases and extensively used as CNS depressant traditionally. The interesting things of this plant are each part of Moringa oleifera is used as medicines. The present work has been carried out to evaluate the anti-epileptic activity of fresh fruit juice of Moringa oleifera against maximal electroshock (M.E.S) and Picrotoxin (PTX) induced convulsions in mice at different dose level (100ml/kg. p.o & 50ml/kg. p.o). Diazepam (5mg/kg. p.o) and Phenytoin (25mg/kg. i.p) were used as reference standard drugs. The data obtained indicates that the fresh fruit juice of Moringa oleifera at the dose of (50ml/kg p.o & 100ml/kg p.o) shows anticonvulsant activity against Maximal electroshock and Picrotoxin induced convulsion in mice.