A Meta Analysis on Prognostic Value of Patients with Non-Small Cell Lung Cancer

J. Rui, Lin Yingping, Lijun Gu, Zhiyan Wang, Jing Zuo, Lin Zha
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引用次数: 0

Abstract

Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity using Review Manager version 5.3. The results of analysis were presented as hazard ratio (HR) or odds ratios with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients was conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2 > 50% and P < 0.05, and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival of NSCLC patients (HR = 2.78, 95% CI = 1.51–5.12, P = 0.001). Moreover, NF-κB expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18–0.57, P < 0.0001) and lymph node metastasis (HR = 0.56, 95% CI = 0.38–0.83, P = 0.004). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.
非小细胞肺癌患者预后价值的Meta分析
核因子κB (NF-κB)是一种关键的核转录因子,在多种人类癌症中与预后相关。然而,NF-κB在非小细胞肺癌(NSCLC)中的临床价值仍存在争议。因此,本荟萃分析的目的是基于已发表的文献,准确评估NF-κB表达与NSCLC患者生存预后的关系。系统地检索PubMed、EMBASE和Web of Science数据库寻找潜在的文章。我们的荟萃分析纳入了来自7项符合条件的研究的1159例患者,这些研究比较了NF-κB表达水平在非小细胞肺癌中的预后意义。使用Review Manager 5.3版本进行I2统计量和P值评估异质性。分析结果以风险比(HR)或95%置信区间(95% CI)的优势比表示。基于非小细胞肺癌患者的种族进行亚组分析,以说明潜在的差异。I2 > 50%, P < 0.05认为异质性显著,采用随机效应模型。综合结果显示,NF-κB表达升高与NSCLC患者总生存期缩短相关(HR = 2.78, 95% CI = 1.51 ~ 5.12, P = 0.001)。此外,NF-κB表达与肿瘤分期(HR = 0.32, 95% CI = 0.18-0.57, P < 0.0001)和淋巴结转移(HR = 0.56, 95% CI = 0.38-0.83, P = 0.004)密切相关。我们得出结论,NF-κB表达可能是非小细胞肺癌患者潜在的不利预后指标。
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来源期刊
Journal of Medical Imaging and Health Informatics
Journal of Medical Imaging and Health Informatics MATHEMATICAL & COMPUTATIONAL BIOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Journal of Medical Imaging and Health Informatics (JMIHI) is a medium to disseminate novel experimental and theoretical research results in the field of biomedicine, biology, clinical, rehabilitation engineering, medical image processing, bio-computing, D2H2, and other health related areas. As an example, the Distributed Diagnosis and Home Healthcare (D2H2) aims to improve the quality of patient care and patient wellness by transforming the delivery of healthcare from a central, hospital-based system to one that is more distributed and home-based. Different medical imaging modalities used for extraction of information from MRI, CT, ultrasound, X-ray, thermal, molecular and fusion of its techniques is the focus of this journal.
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