Toxic Effects of Sexual Drug Overdose: Sildenafil (Viagra)

Abstract

Sildenafil is the sexual drug. Sildenafil is a new oral drug specially aimed at the cure of erectile dysfunction [1]. Sildenafil citrate is a discerning inhibitor of phosphodiesterase 5 (PDE5) and stayed the initial agent through this way of act for the cure of man erectile dysfunction [2]. Male erectile dysfunction (ED) is the determined or recurring incapability to reach, or to uphold till end of the sexual action, a suitable erection [3]. Sildenafil (Viagra) conventional Food and Drug Administration approval in March 1998 such as the earliest oral agent for erectile dysfunction [4]. Sildenafil workings such as a modest inhibitor of an enzyme of the phosphodiesterase type five class (PDE-5). Here are eleven forms of phosphodiesterase found over the body [5, 6]. Sildenafil is a weak vasodilator, resultant in lesser, transitory decreases in systolic (10 mmHg) and diastolic (7 mmHg) blood pressure (BP) when directed orally; no clinically important special effects on heart rate (HR) have been stated [7]. Sildenafil is quickly engrossed, by maximum plasma concentrations happening in one hour after oral admin then a mean fatal half-life of three to five hours [5]. Since the approval of sildenafil, several information of unexpected death amid patients preserved by this drug have upraised about worries concerning its care in patients with coronary artery disease [8].