Enzymatic Modification of Aminoglycoside Antibiotics in Gentamicin-Resistant Gram-Negative Bacteria

Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious... Pub Date : 1984-08-01 DOI:10.1016/S0174-3031(84)80063-3

Milan Kettner , Jana Navarová , Gerhard Lebek , Vladimir Krcméry

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引用次数: 3

Abstract

An in vitro evaluation of 32 gentamicin-resistant, Gram-negative bacteria from hygiene-centres in Berne, Switzerland and Bratislava, Czechoslovakia, revealed that 24 strains produced gentamicin-modifying enzymes. Occurrence of acetyltransferases (AAC) was confirmed in 16 strains, adenylyltransferase (AAD) /2″/ was observed in 13 strains while 5 of the gentamicin-resistant strains produced both enzymes. All Czechoslovak strains were amikacin-susceptible, in amikacin-resistant Pseudomonas aeruginosa strains from Switzerland the presence of AAC/6′/ was found. In the majority of gentamicin-resistant, netilmicin-susceptible strains the occurrence of AAD/2″/ was observed. Gentamicin-resistance in the modifying enzymes producing strains was due either to production of an acetyltransferase or the adenylyltransferase except Swiss strains of Serratia marcescens where a simultaneous production of both types of the enzymes was noted. Twenty eight strains produced an enzyme modifying animoglycosides of any kind.

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对庆大霉素耐药革兰氏阴性菌氨基糖苷类抗生素的酶修饰

对来自瑞士伯尔尼和捷克斯洛伐克布拉迪斯拉发卫生中心的32种对庆大霉素耐药的革兰氏阴性细菌的体外评价显示，24株菌株产生庆大霉素修饰酶。16株菌株检测到乙酰转移酶(AAC)， 13株菌株检测到腺苷基转移酶(AAD) /2″/，5株菌株同时检测到这两种酶。所有捷克斯洛伐克菌株对阿米卡霉素敏感，在耐阿米卡霉素的瑞士铜绿假单胞菌菌株中发现了AAC/6′/。在大多数庆大霉素耐药、奈替米星敏感菌株中均观察到AAD/2″/的发生。修饰酶产生菌株的庆大霉素抗性是由于乙酰转移酶或腺苷转移酶的产生，但粘质沙雷氏菌瑞士菌株同时产生两种类型的酶是注意到的。28株菌株产生一种酶修饰任何种类的动物糖苷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...

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