{"title":"Renal clearance of sodium and potassium in hypothermia.","authors":"G. S. Kanter","doi":"10.1139/O62-015","DOIUrl":null,"url":null,"abstract":"The handling of sodium and potassium by the renal tubules at various levels of hypothermia was studied. Fourteen dogs were anesthetized with 30 mg/kg sodium pentobarbital. After suitable control clearance measurements, the rectal temperature was lowered progressively by ice-packing to about 25 °C while renal clearances were continuously measured. Artificial respiration was not used. No change in plasma sodium was detected but plasma potassium fell significantly from a control value of 4.1 ± 0.09 meq/1. at 38 °C to 3.4 ± 0.12 meq/1. at 25 °C. Urine sodium concentration fell during exposure to cold while potassium concentration increased slightly. In spite of the marked fall in glomerular nitration rate (69.0 ± 3.1 ml/minute control to 17.0 ± 3.6 ml/minute at 25 °C) the final urine flow at 25 °C was slightly greater than that of control. The clearance ratios (in percentage) increased significantly, reflecting the marked decrease in tubular reabsorption: water, 0.49 ± 0.05 at 38 °C to 2.02 ± 0.25 at 25 °C; s...","PeriodicalId":90304,"journal":{"name":"Project report. USAF School of Aviation Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1961-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Project report. USAF School of Aviation Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1139/O62-015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
The handling of sodium and potassium by the renal tubules at various levels of hypothermia was studied. Fourteen dogs were anesthetized with 30 mg/kg sodium pentobarbital. After suitable control clearance measurements, the rectal temperature was lowered progressively by ice-packing to about 25 °C while renal clearances were continuously measured. Artificial respiration was not used. No change in plasma sodium was detected but plasma potassium fell significantly from a control value of 4.1 ± 0.09 meq/1. at 38 °C to 3.4 ± 0.12 meq/1. at 25 °C. Urine sodium concentration fell during exposure to cold while potassium concentration increased slightly. In spite of the marked fall in glomerular nitration rate (69.0 ± 3.1 ml/minute control to 17.0 ± 3.6 ml/minute at 25 °C) the final urine flow at 25 °C was slightly greater than that of control. The clearance ratios (in percentage) increased significantly, reflecting the marked decrease in tubular reabsorption: water, 0.49 ± 0.05 at 38 °C to 2.02 ± 0.25 at 25 °C; s...