The theoretical and experimental substantiation of the composition of a mouthwash

Abstract

Aim. To develop the composition and laboratory technology of a therapeutic and preventive mouthwash based on a plant active ingredient and study a number of its quality indicators. Materials and methods. When developing the composition and technology of the drug, active pharmaceutical ingredients (APIs) and excipients approved for medical use and widely used in pharmaceutical practice were selected. The information-search, information-analytical, organoleptic, physicochemical, pharmacotechnological and microbiological research methods were used. Statistical processing of the data obtained was performed using Microsoft Excel 2007 spreadsheets. Results and discussion. The composition and number of components of the therapeutic and preventive mouthwash have been theoretically substantiated. The theoretical and experimental substantiation of the composition of the original mouthwash of the multifaceted action with a deodorizing effect for use in halitosis (the liquid extract of burdock, pot marigold, fleaworts, horsetail, sage, inula, chicory (45 : 5 : 15 : 5 : 10 : 15 : 5, respectively) (1 : 4); thyme and lemon essential oil, xylitol, polysorbate-20, glycerin, PEG-40 hydrogenated castor oil, purified water) is given. The tests showed the need to add antimicrobial preservatives to the mouthwash composition. Taking into account the requirements of safety and cost-effectiveness, as well as slightly higher antimicrobial activity, potassium sorbate in the minimum effective concentration of 0.1 % was chosen as a promising preservative. Salivary diagnostics revealed a general tendency to improve the physicochemical properties of saliva by a number of parameters after applying an experimental sample of the mouthwash developed. There is a general tendency to improve the physicochemical properties of saliva by a number of parameters after using an experimental sample of the mouthwash developed. Conclusions. The composition of the therapeutic and preventive original drug – a mouthwash of the multifaceted action with the antimicrobial and deodorizing effects for use in halitosis has been developed.