THE EFECT OF IMMUNOMODULATOR BY EXTRACT ETHANOL OF HERBA BINARA (ARTEMISIA VULGARIS L.) TOWARD THE RESPONSE OF DELAYED-TYPE HYPERSENSITIVITY IN RAT MALE

Jurnal Penelitian Farmasi & Herbal Pub Date : 2018-10-17 DOI:10.36656/jpfh.v1i1.59

Romauli Anna teresia Marbun, N. Situmorang, S. Wahyuni

{"title":"THE EFECT OF IMMUNOMODULATOR BY EXTRACT ETHANOL OF HERBA BINARA (ARTEMISIA VULGARIS L.) TOWARD THE RESPONSE OF DELAYED-TYPE HYPERSENSITIVITY IN RAT MALE","authors":"Romauli Anna teresia Marbun, N. Situmorang, S. Wahyuni","doi":"10.36656/jpfh.v1i1.59","DOIUrl":null,"url":null,"abstract":"Immunomodulator is a compound that can increaase the imuno system. One of the plants that have immunomodulator’s activity is Herba Binara (Artemisia vulgaris L.). the purpose of this research was to test the effect of immunomodulator by extract of herba binara ethanol on rat male. The activity of immunomodulator was determined by using digital pletysmometer by measuring the differences between the last leg swelling’s volume and the first leg swelling’s volume. The treatment group were divided into 5 groups. Each group consistof 5 rats CMC-Na 0,5% (negative control), Imboost 32,5 mg/kgBW (positive control), dose of EEHB 50, 100, 200 mg/kgBW, and bacteria E.coli as antigen. The results slowed that distribution of EEHB dose 200 mg/kgBW can give the effect of immunostimulant by swelling enthancement compared by CMC-Na 0,5 %. EEHB 200 mg/kgBW that have activity comparable with Imboost 32,5 mg/kgBW. Thus, it is concluded that of herba binara extract has immunomodulator effects on delayed-type hypersensitivity response of rat male.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"14 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Penelitian Farmasi & Herbal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36656/jpfh.v1i1.59","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

Abstract

Immunomodulator is a compound that can increaase the imuno system. One of the plants that have immunomodulator’s activity is Herba Binara (Artemisia vulgaris L.). the purpose of this research was to test the effect of immunomodulator by extract of herba binara ethanol on rat male. The activity of immunomodulator was determined by using digital pletysmometer by measuring the differences between the last leg swelling’s volume and the first leg swelling’s volume. The treatment group were divided into 5 groups. Each group consistof 5 rats CMC-Na 0,5% (negative control), Imboost 32,5 mg/kgBW (positive control), dose of EEHB 50, 100, 200 mg/kgBW, and bacteria E.coli as antigen. The results slowed that distribution of EEHB dose 200 mg/kgBW can give the effect of immunostimulant by swelling enthancement compared by CMC-Na 0,5 %. EEHB 200 mg/kgBW that have activity comparable with Imboost 32,5 mg/kgBW. Thus, it is concluded that of herba binara extract has immunomodulator effects on delayed-type hypersensitivity response of rat male.

查看原文本刊更多论文

双叶蒿(artemisia vulgaris l .)提取物乙醇对免疫调节剂的作用雄性大鼠迟发性超敏反应的研究

免疫调节剂是一种能增强免疫系统的化合物。具有免疫调节剂活性的植物之一是黄花蒿(Artemisia vulgaris L.)。本研究旨在探讨中药乙醇提取物对雄性大鼠免疫调节剂的作用。免疫调节剂的活性采用数字式容积计，通过测量末次腿肿胀量与初次腿肿胀量的差异来测定。治疗组分为5组。每组5只大鼠，CMC-Na 0.5%(阴性对照)，Imboost 32.5 mg/kgBW(阳性对照)，EEHB剂量50、100、200 mg/kgBW，以大肠杆菌为抗原。结果表明，与CMC-Na 0.5%相比，EEHB剂量200 mg/kgBW可通过肿胀增强发挥免疫刺激作用。EEHB 200 mg/kgBW，活性与Imboost 32,5 mg/kgBW相当。由此可见，双头草提取物对雄性大鼠迟发性超敏反应具有免疫调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Jurnal Penelitian Farmasi & Herbal

自引率

0.00%

发文量