Hip and Knee Osteoarthritis: An Overvıew

A. Aslan
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Abstract

Osteoarthritis (OA) is currently the most common musculoskeletal disease causing significant pain, disability and socioeconomic costs worldwide. It primarily affects weight-bearing joints such as the knees and hips. It is the leading cause of disability in older adults causes pain, loss of function and impaired quality of life. The etiopathology of OA is complex and multifactorial with genetic, biological and biomechanical components. OA was previously thought to be simply a "wear and tear" disease predominantly associated with aging, and mechanically driven. However, it is now known that it is a much more complex process including mechanic, inflammatory and metabolic factors. Most clinical studies of hip and knee OA have focused primarily on improvement in pain and joint function. Current treatment methods do not seem to be sufficient to stop the course of OA, and functional outcomes may be poor in despite of all treatment modalities. The focus is so now on disease prevention and early OA treatment.
髋关节和膝关节骨关节炎:Overvıew
骨关节炎(OA)是目前最常见的肌肉骨骼疾病,在世界范围内引起严重的疼痛、残疾和社会经济成本。它主要影响负重关节,如膝盖和臀部。它是老年人致残的主要原因,会导致疼痛、功能丧失和生活质量受损。骨性关节炎的病因是复杂的、多因素的,包括遗传、生物学和生物力学因素。OA以前被认为是一种简单的“磨损”疾病,主要与衰老有关,并且是机械驱动的。然而,现在我们知道,这是一个复杂得多的过程,包括机械、炎症和代谢因素。大多数髋关节和膝关节OA的临床研究主要集中在疼痛和关节功能的改善上。目前的治疗方法似乎不足以阻止骨关节炎的进程,尽管采用了各种治疗方式,但功能结果可能很差。现在的重点是疾病预防和早期OA治疗。
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