Evaluation of Three-year Overall and Disease-free Survival in Iranian Patients with Nasopharyngeal Carcinoma Treated by Intensity-modulated Radiotherapy (IMRT): A Historical Cohort Single Center Study

IF 0.4 Q4 ONCOLOGY

International Journal of Cancer Management Pub Date : 2023-06-11 DOI:10.5812/ijcm-136257

Maryam Kalantari Khandani, S. Azghandi, Z. Siavashpour, A. Rakhsha, Amir Shahram Yousefi Kashi, Arian Yousefi Kashi

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引用次数: 0

Abstract

Background: The aim of this study was to evaluate and analyze disease-free survival (DFS) and overall survival (OS) after intensity-modulated radiotherapy (IMRT) for Iranian patients with nasopharyngeal carcinoma (NC). Methods: In this historical cohort study, 65 non-metastatic patients treated for NC with IMRT were selected and reviewed at the Shohadai-e-Tajrish Hospital between October 2017 and October 2019. Chemotherapy was given either as induction, concurrent, or adjuvant therapy in all cases. Three years of DFS and OS were calculated according to Kaplan-Meier and compared with the Pearson Correlation Test. Results: The mean age of patients was 43.38 years. The three-year DFS and OS rates were 95.72%, 92.32%, 72.73%, 73.26%, and 100%, 84.61%, 90.90%, and 79.41% in stage I, II, III, and IV patients, respectively (P = 0.119, P = 0.155). The total three-year DFS rate and the total three-year OS rate were 76.47% and 84.60% in all cases. Based on the Pearson Correlation Test, it was a significant correlation between the duration of IMRT time and three-year DFS (correlation=0.138, P = 0.017) and the number of concurrent cycles of chemotherapy with IMRT (correlation=0.375, P = 0.002). It was not a significant correlation between total time duration, MRI response, induction chemotherapy, age, sex, and the three-year DFS. There was a significant correlation between total time duration and three-year OS (correlation=0.263, P = 0.040) and the number of concurrent cycles of chemotherapy with IMRT and three-year OS (correlation=0.334, P = 0.007). It was not a significant correlation between the duration of IMRT time, MRI response, induction chemotherapy, age, sex, and the three-year OS. Conclusions: Our findings showed that IMRT with concurrent chemo-radiotherapy has the three-year DFS and OS, which were comparable with the other published results. We emphasize the number of concurrent cycles of chemotherapy with IMRT, which have an important role in both three-year DFS and OS. The duration of IMRT time has also an important role in the three-year DFS but not in the three-year OS. A longer follow-up for the patients to evaluate 10-year DFS and OS is recommended.

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伊朗鼻咽癌患者接受调强放疗(IMRT)治疗的三年总生存率和无病生存率评估:一项历史队列单中心研究

背景:本研究的目的是评估和分析伊朗鼻咽癌(NC)患者调强放疗(IMRT)后的无病生存期(DFS)和总生存期(OS)。方法:在这项历史队列研究中，选择并回顾了2017年10月至2019年10月在Shohadai-e-Tajrish医院接受IMRT治疗的65例非转移性NC患者。化疗在所有病例中作为诱导、同时或辅助治疗给予。采用Kaplan-Meier法计算3年DFS和OS，并采用Pearson相关检验进行比较。结果:患者平均年龄43.38岁。I期、II期、III期和IV期患者的3年DFS和OS分别为95.72%、92.32%、72.73%、73.26%和100%、84.61%、90.90%和79.41% (P = 0.119, P = 0.155)。3年总DFS率为76.47%，3年总OS率为84.60%。Pearson相关检验显示，IMRT时间与3年DFS(相关性=0.138,P = 0.017)与IMRT同时化疗周期数(相关性=0.375,P = 0.002)具有显著相关性。总时间、MRI反应、诱导化疗、年龄、性别和3年DFS之间无显著相关性。总时间与3年OS(相关性=0.263,P = 0.040)、联合IMRT化疗同时周期数与3年OS(相关性=0.334,P = 0.007)有显著相关性。IMRT时间、MRI反应、诱导化疗、年龄、性别和3年OS之间无显著相关性。结论:我们的研究结果显示，同步放化疗的IMRT具有3年的DFS和OS，与其他已发表的结果相当。我们强调化疗与IMRT同时进行的周期数，这对3年DFS和OS都有重要作用。IMRT时间的长短对3年DFS也有重要影响，但对3年OS没有影响。建议对患者进行更长的随访以评估10年DFS和OS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Cancer Management ONCOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： International Journal of Cancer Management (IJCM) publishes peer-reviewed original studies and reviews on cancer etiology, epidemiology and risk factors, novel approach to cancer management including prevention, diagnosis, surgery, radiotherapy, medical oncology, and issues regarding cancer survivorship and palliative care. The scope spans the spectrum of cancer research from the laboratory to the clinic, with special emphasis on translational cancer research that bridge the laboratory and clinic. We also consider original case reports that expand clinical cancer knowledge and convey important best practice messages.