Evaluation of Antithyroid Antibodies in Polycystic Ovarian Syndrome of Reproductive Women

Journal of Chittagong Medical College Teachers' Association Pub Date : 2021-12-31 DOI:10.3329/jcmcta.v32i2.66514

S. Akhter, N. Tasnim, Mohammed Hafizul Islam, Pervin Akter, Pijush Karmakar, Ummey Salma

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Abstract

Background: Polycystic Ovarian Syndrome (PCOS) is common but a treatable cause of infertility in reproductive women. Thyroid hormone abnormality is commonly seen in Polycystic Ovarian Syndrome of reproductive women. Antithyroid antibodies have been detected in women with PCOS. The aim of the present study is to evaluate the antithyroid antibodies in Polycystic Ovarian Syndrome (PCOS) of reproductive women. Materials and methods: A hospital based cross-sectional comparative study was conducted in the outpatient Department of Obstetrics and Gynaecology in CMCH, Institute of Nuclear Medicine and Allied Subject and the Department of Biochemistry in CMC. Eighty (80) PCOS women diagnosed by ultrasonography were taken by nonprobability convenient sampling, considered as group A and another twenty (20) healthy women were taken, considered as group B. Important variables in this study were serum anti-TPO antibody, anti-Tg antibody, TSH, age, menstrual history, hirsutism, waist circumference and BMI. Results: This study revealed a statistically significant higher prevalence of autoimmune thyroiditis in PCOS cases in comparison to healthy group (32.5 % and 37.5% patients had increased anti-TPO and anti-Tg antibodies respectively). Mean serum anti-TPO and anti-Tg antibodies were increased significantly in PCOS cases than that of healthy women group. Mean serum TSH was not increased significantly in PCOS cases than that of healthy group.52.5%, 47.5% patients had oligomenorrhea and amenorrhea respectively, 21.2% had hirsutism, 68.8% cases were overweight & obese and 77.5% were central obese. Conclusion: High prevalence of thyroid autoimmunity in euthyroid PCOS patients refers to the importance of screening not only thyroid hormone levels but also thyroid antibody level during the investigation of PCOS of reproductive women and thereby early diagnosis and management of infertility associated with PCOS. JCMCTA 2021 ; 32 (2) : 105-110

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生殖期妇女多囊卵巢综合征抗甲状腺抗体的评价

背景:多囊卵巢综合征(PCOS)是一种常见但可治疗的育龄妇女不孕原因。甲状腺激素异常常见于生殖期妇女多囊卵巢综合征。在多囊卵巢综合征患者中检测到抗甲状腺抗体。本研究的目的是评估多囊卵巢综合征(PCOS)育龄妇女的抗甲状腺抗体。材料与方法:采用以医院为单位的横断面对比研究，分别在中医医院妇产科门诊、核医学及相关学科研究所、生物化学系进行对比研究。采用非概率方便抽样法，选取超声诊断为PCOS的女性80例作为A组，选取健康女性20例作为b组。本研究的重要变量为血清抗tpo抗体、抗tg抗体、TSH、年龄、月经史、多毛、腰围、BMI。结果:本研究显示，与健康组相比，PCOS患者自身免疫性甲状腺炎的患病率有统计学意义(32.5%和37.5%的患者抗tpo和抗tg抗体分别升高)。PCOS患者血清抗tpo抗体和抗tg抗体均明显高于正常对照组。PCOS患者血清TSH均值较健康组无明显升高，经少、闭经分别为52.5%、47.5%，多毛21.2%，超重肥胖68.8%，中心性肥胖77.5%。结论:正常甲状腺型多囊卵巢综合征患者甲状腺自身免疫发生率高，说明在调查生殖期妇女多囊卵巢综合征时，不仅要筛查甲状腺激素水平，还要筛查甲状腺抗体水平，以便早期诊断和治疗多囊卵巢综合征相关不孕。Jcmcta 2021;32 (2): 105-110

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Journal of Chittagong Medical College Teachers' Association

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