Growth of teeth and bones in adult subjects with congenital untreated isolated growth hormone deficiency

IF 1.6 4区 医学 Q4 CELL BIOLOGY
Luiz A. Oliveira-Neto , Jéssica K.F. Nascimento , Roberto Salvatori , Alécia A. Oliveira-Santos , Rafaela S. Girão , Evânio V. Silva , André L.M. Santos , Matheus M. Cunha , Marcos A.V. Bittencourt , Gustavo T. Rodrigues , Bruna M.R. Andrade , Alaíde H.A. Oliveira , Eugênia H.O. Valença , Manuel H. Aguiar-Oliveira
{"title":"Growth of teeth and bones in adult subjects with congenital untreated isolated growth hormone deficiency","authors":"Luiz A. Oliveira-Neto ,&nbsp;Jéssica K.F. Nascimento ,&nbsp;Roberto Salvatori ,&nbsp;Alécia A. Oliveira-Santos ,&nbsp;Rafaela S. Girão ,&nbsp;Evânio V. Silva ,&nbsp;André L.M. Santos ,&nbsp;Matheus M. Cunha ,&nbsp;Marcos A.V. Bittencourt ,&nbsp;Gustavo T. Rodrigues ,&nbsp;Bruna M.R. Andrade ,&nbsp;Alaíde H.A. Oliveira ,&nbsp;Eugênia H.O. Valença ,&nbsp;Manuel H. Aguiar-Oliveira","doi":"10.1016/j.ghir.2022.101469","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To understand the growth of teeth and mandibular and maxillary bones in subjects with isolated growth hormone deficiency (IGHD).</p></div><div><h3>Material and methods</h3><p>Mesiodistal tooth width of 28 maxillary and mandibular dental models of 14 adult IGHD subjects (9 men) were digitalized and compared to 40 models of 20 normal-statured controls (11 men). The mean SDS of the maxillary and mandibular teeth were compared with height, cephalic perimeter, total anterior facial height, total maxillary and mandibular length, and maxillary and mandibular arches.</p></div><div><h3>Results</h3><p><span>All average mesiodistal dimensions in absolute values of the 14 dental pairs were reduced in the IGHD group. Eight of 28 (28.6%) mesiodistal dimensions in IGHD subjects of both sexes had an average SDS below −2, thirteen of them (46.4%) had mean SDS between −1 and − 2, and seven of them (25.0%) had SDS above −1. The highest SDS values were the upper lateral incisor (−0.32 in women), and the </span>upper canine<span> (−0.91 in men). The lowest SDS values were the 2nd upper molar (−3.51 in men), and the 2nd upper premolar (−2.64 in women). The ascending order of the mean SDS was height, total maxillary length, total mandibular length, total anterior height of the face, cephalic perimeter, the maxillary arches width, the mesiodistal width of the mandibular teeth, the mesiodistal width of the maxillary teeth and the mandibular arches width.</span></p></div><div><h3>Conclusions</h3><p>Reduction in mesiodistal width is present in untreated IGHD adults with magnitude of tooth size reduction being lower than height, cephalic perimeter, total anterior facial height, and most jaw measurements. IGHD abolishes the sexual dimorphism in mesiodistal dental measures.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637422000260","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 4

Abstract

Objective

To understand the growth of teeth and mandibular and maxillary bones in subjects with isolated growth hormone deficiency (IGHD).

Material and methods

Mesiodistal tooth width of 28 maxillary and mandibular dental models of 14 adult IGHD subjects (9 men) were digitalized and compared to 40 models of 20 normal-statured controls (11 men). The mean SDS of the maxillary and mandibular teeth were compared with height, cephalic perimeter, total anterior facial height, total maxillary and mandibular length, and maxillary and mandibular arches.

Results

All average mesiodistal dimensions in absolute values of the 14 dental pairs were reduced in the IGHD group. Eight of 28 (28.6%) mesiodistal dimensions in IGHD subjects of both sexes had an average SDS below −2, thirteen of them (46.4%) had mean SDS between −1 and − 2, and seven of them (25.0%) had SDS above −1. The highest SDS values were the upper lateral incisor (−0.32 in women), and the upper canine (−0.91 in men). The lowest SDS values were the 2nd upper molar (−3.51 in men), and the 2nd upper premolar (−2.64 in women). The ascending order of the mean SDS was height, total maxillary length, total mandibular length, total anterior height of the face, cephalic perimeter, the maxillary arches width, the mesiodistal width of the mandibular teeth, the mesiodistal width of the maxillary teeth and the mandibular arches width.

Conclusions

Reduction in mesiodistal width is present in untreated IGHD adults with magnitude of tooth size reduction being lower than height, cephalic perimeter, total anterior facial height, and most jaw measurements. IGHD abolishes the sexual dimorphism in mesiodistal dental measures.

先天性未经治疗的孤立性生长激素缺乏症的成人受试者的牙齿和骨骼生长
目的了解孤立性生长激素缺乏症(IGHD)患者牙齿及下颌骨的生长情况。材料与方法对14例成人IGHD患者(男性9例)的28个上颌和下颌牙模型进行数字化处理,并与20例正常对照组(男性11例)的40个模型进行比较。比较上颌牙和下颌牙的平均SDS与高度、头侧周长、前面总高度、上颌和下颌总长度以及上颌和下颌弓的差异。结果IGHD组14对牙的中、远端平均尺寸绝对值均降低。男女IGHD受试者中28个中远端维度中有8个(28.6%)的平均SDS低于- 2,13个(46.4%)的平均SDS介于- 1和- 2之间,7个(25.0%)的SDS高于- 1。SDS值最高的是上侧切牙(女性为- 0.32)和上犬齿(男性为- 0.91)。SDS值最低的是第2上臼齿(男性为−3.51)和第2上前臼齿(女性为−2.64)。平均SDS由高到高依次为:上颌总长度、下颌总长度、面部前总高度、头侧周长、上颌弓宽度、下颌牙近远端宽度、上颌牙近远端宽度、下颌弓宽度。结论未治疗的成人IGHD患者存在近远端宽度缩小,且牙齿大小缩小的幅度低于身高、头侧周长、面部前高度和大多数颌骨测量值。IGHD消除了中远端牙齿的性别二态性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信