Chimerism Analysis of Children with Allogeneic Stem-Cell transplantation and Its Effect on Survival

Abstract

the only curative treatment for many congenital and acquired, malignant and non-malignant diseases of the childhood Donor cell engraftment is a critical step in the success of Allo-HSCT. However, engraftment does not always result in a definite status and we may end up with mixed chimerism. Mixed chimerism is a state where both the recipient and donor hematopoietic stem cells coexist in the host’s bone marrow. 4 Although malignancies by -3.04 (-4.00 to -2.08) [hazard ratio (HR): 0.05 (p<0.001)]. Neutrophil engraftment was the other factor which was positively correlated with EFS (HR p-value: 0.05) CONCLUSION: There is a positive correlation between CS in the first 100 days and EFS for both malignant and non-malignant diseases.