EVALUATION OF ANAESTHETIC CHARACTERISTICS OF PROPOFOL IN NON-PREMEDICATED RABBITS WITH EXPERIMENTALLY INDUCED POST RENAL UNILATERAL URETERAL OBSTRUCTION

Animal Research International Pub Date : 2017-01-08 DOI:10.4314/ARI.V14I1

V. Oleforuh-Okoleh, Romanus Francis Kurutsi, Hanson Modhiochi Ideozu

{"title":"EVALUATION OF ANAESTHETIC CHARACTERISTICS OF PROPOFOL IN NON-PREMEDICATED RABBITS WITH EXPERIMENTALLY INDUCED POST RENAL UNILATERAL URETERAL OBSTRUCTION","authors":"V. Oleforuh-Okoleh, Romanus Francis Kurutsi, Hanson Modhiochi Ideozu","doi":"10.4314/ARI.V14I1","DOIUrl":null,"url":null,"abstract":"This study was carried out to investigate the anaesthetic characteristics of propofol in rabbits with unilateral ureteral obstruction. Rabbits in two groups (B and C) were anaesthetized respectively with 10 mg/kg propofol intravenously (IV) on days 7 and 14 post unilateral ureteral obstruction (UUO). Healthy rabbits in group A served as the control group and were anaesthetized with propofol (10 mg/kg, IV). Duration of anaesthesia obtained in the control group was significantly (p 0.05) while white blood cell counts of rabbits decreased PPI. Total serum protein (TSP) and blood urea nitrogen levels of the three groups of rabbits increased PPI though not significantly (p>0.05) PPI. Serum potassium, chlorine and bicarbonate levels of rabbits in all the three study groups increased PPI. Propofol at the dose used in this study induced rapid induction and recovery from anaesthesia, adequate depth of anaesthesia with no untoward haematologic and serum biochemical effects in UUO rabbits. However it’s marked respiratory depressant effect and ability to increase serum potassium levels may preclude its use in advanced UUO.","PeriodicalId":7872,"journal":{"name":"Animal Research International","volume":"36 1","pages":"2568-2575"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"17","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Research International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ARI.V14I1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 17

Abstract

This study was carried out to investigate the anaesthetic characteristics of propofol in rabbits with unilateral ureteral obstruction. Rabbits in two groups (B and C) were anaesthetized respectively with 10 mg/kg propofol intravenously (IV) on days 7 and 14 post unilateral ureteral obstruction (UUO). Healthy rabbits in group A served as the control group and were anaesthetized with propofol (10 mg/kg, IV). Duration of anaesthesia obtained in the control group was significantly (p 0.05) while white blood cell counts of rabbits decreased PPI. Total serum protein (TSP) and blood urea nitrogen levels of the three groups of rabbits increased PPI though not significantly (p>0.05) PPI. Serum potassium, chlorine and bicarbonate levels of rabbits in all the three study groups increased PPI. Propofol at the dose used in this study induced rapid induction and recovery from anaesthesia, adequate depth of anaesthesia with no untoward haematologic and serum biochemical effects in UUO rabbits. However it’s marked respiratory depressant effect and ability to increase serum potassium levels may preclude its use in advanced UUO.

查看原文本刊更多论文

异丙酚对实验性肾后单侧输尿管梗阻家兔非预用药的麻醉特性评价

本研究探讨异丙酚对单侧输尿管梗阻家兔的麻醉特性。B组和C组分别于单侧输尿管梗阻(UUO)后第7天和第14天静脉注射10 mg/kg异丙酚麻醉。A组健康家兔为对照组，以异丙酚(10 mg/kg，静脉)麻醉，对照组麻醉时间显著延长(p 0.05)，白细胞计数明显降低PPI。三组家兔血清总蛋白(TSP)和血尿素氮水平均升高了PPI，但未显著升高(p>0.05)。三个研究组兔血清钾、氯和碳酸氢盐水平均升高PPI。本研究中使用的剂量异丙酚能使UUO家兔快速诱导和恢复麻醉，麻醉深度足够，无不良血液学和血清生化影响。然而，它明显的呼吸抑制作用和提高血清钾水平的能力可能使其无法用于晚期UUO。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Animal Research International

自引率

0.00%

发文量