Abstract A061: STING, an immune biomarker for colorectal cancer

Tackling the Tumor Microenvironment: Beyond T-cells Pub Date : 2019-02-01 DOI:10.1158/2326-6074.CRICIMTEATIAACR18-A061

H. Chon, Chan Kim

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Abstract

Background: STING is an innate immune sensor for cytosolic DNA. The activation of STING signaling is indispensable in Type I interferon response and the evocation of anticancer immune response by CD8+ T-cells. The aim of this study is to characterize intratumoral STING expression pattern and its clinical implication in colorectal cancer (CRC). Methods: We analyzed STING and CD8 expression in 225 CRC patients who underwent surgical resection. Clinicopathologic variables and survival outcomes were analyzed according to STING expression level. Results: Distinct STING expression was observed in tumor specimens of CRCs. Patients with higher STING expression seemed to have early stage cancer (P = 0.001) with increased intratumoral CD8+ T-cell infiltration (P Citation Format: Hongjae Chon, Chan Kim. STING, an immune biomarker for colorectal cancer [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A061.

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摘要/ Abstract摘要:STING是结直肠癌的免疫生物标志物

背景:STING是细胞质DNA的先天免疫传感器。在I型干扰素应答和CD8+ t细胞抗癌免疫应答中，STING信号的激活是必不可少的。本研究的目的是表征结直肠癌(CRC)肿瘤内STING表达模式及其临床意义。方法:我们分析了225例手术切除的结直肠癌患者中STING和CD8的表达。根据STING表达水平分析临床病理指标及生存结果。结果:在肿瘤标本中观察到明显的STING表达。STING表达较高的患者似乎患有早期癌症(P = 0.001)，肿瘤内CD8+ t细胞浸润增加(P引用格式:Hongjae Chon, Chan Kim)。结直肠癌的免疫生物标志物STING[摘要]。第四届CRI-CIMT-EATI-AACR国际癌症免疫治疗会议:将科学转化为生存;2018年9月30日至10月3日;纽约，纽约。费城(PA): AACR;癌症免疫杂志2019;7(2增刊):摘要nr A061。

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Tackling the Tumor Microenvironment: Beyond T-cells

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