Vineland Adaptive Behavior Scales to Identify Neurodevelopmental Outcomes in Children with Congenital Hypothyroidism

Q4 Medicine

Egyptian Journal of Ear, Nose, Throat and Allied Sciences Pub Date : 2021-01-01 DOI:10.21608/ejentas.2021.66743.1327

H. Nazif, H. Kamal, Dina M. Khaled, Samer Elkhayat, A. Ramzy

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引用次数: 0

Abstract

Background: Congenital hypothyroidism (CH) is the most common preventable causes of mental retardation in children. Screening and early treatment an important prognostic factors for normal neurodevelopment in children with CH. The Vineland Adaptive Behavior Scales Second Edition (VABS-II) is a parent report measure of adaptive functioning that could be used as a developmental screening tool in patients with CH. We have investigated the performance of VABS-II as a screening tool to identify developmental delay in children with CH. VABS-II questionnaires testing communication, daily living skills, social skills, motor skills and behaviour domains were completed by parents of 50 children with CH initially at time of diagnosis and follow up after six month with age distribution 3rd day of life 12 months (CH, n = 35) and 1324 months (CH, n = 15). Both had positive results of screening program and positive values for thyroid function tests. Objective: The aim of this study to assess and follow up neurodevelopmental abilities in children with congenital hypothyroidism using Vineland Adaptive Behavior Scales-Second Edition (Vineland-II). Patients and Methods: We conducted a prospective study at Benha Children Hospital, Egypt. The study participants were 50 infants with CH and their mothers (patients group), and 50 age matched volunteers of healthy infants (control group). Data were collected to determine socioeconomic state, clinical picture at presentation, personal, family, obstetric history and assessment of neurodevelopment by using Vineland-II scale. Results: About 64% of cases were permanent CH and about 14% of cases were transient CH. There was significant positive correlation between compliance score and the parameters of the physical and neurological development. Conclusion: Our study adds further evidence to normalize TSH as soon as possible to avoid long-term neurodevelopmental outcomes.

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Vineland适应性行为量表识别先天性甲状腺功能减退症儿童的神经发育结局

背景:先天性甲状腺功能减退症(CH)是儿童智力低下最常见的可预防原因。筛查和早期治疗是影响CH患儿神经正常发育的重要因素。Vineland适应行为量表第二版(VABS-II)是一种家长报告的适应功能测量方法，可以用作CH患者的发育筛查工具。我们研究了VABS-II作为筛查工具的性能，以确定CH患儿的发育迟缓。社交技能、运动技能和行为领域由50名CH患儿的父母在诊断时完成，6个月后随访，年龄分布为生命第3天12个月(CH, n = 35)和1324个月(CH, n = 15)。筛查结果均为阳性，甲状腺功能检查结果均为阳性。目的:应用Vineland适应行为量表-第二版(Vineland- ii)对先天性甲状腺功能减退症患儿的神经发育能力进行评估和随访。患者和方法:我们在埃及Benha儿童医院进行了一项前瞻性研究。研究对象为50名CH患儿及其母亲(患者组)和50名年龄匹配的健康婴儿志愿者(对照组)。收集资料，以确定社会经济状况，临床表现，个人，家庭，产科史和评估神经发育使用Vineland-II量表。结果:永久性CH约占64%，短暂性CH约占14%，依从性评分与患儿身体和神经发育参数呈显著正相关。结论:我们的研究进一步证明了尽快使TSH正常化以避免长期的神经发育后果。

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来源期刊

Egyptian Journal of Ear, Nose, Throat and Allied Sciences Medicine-Otorhinolaryngology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： Egyptian Journal of Ear, Nose, Throat and Allied Sciences aspires to play a national, regional and international role in the promotion of responsible and effective research in the field of Otolaryngology, Head and Neck Surgery in Egypt, Middle East and Africa. Mission To encourage and support research in Ear, Nose and Throat (ENT) field and interdisciplinary topics To implement high-quality editorial practices among Otolaryngologists To upgrade the ability and experience of local doctors in international publishing To offer professional publishing support to local researchers, creating a supportive network for career development To highlight ENT diseases and problems peculiar to our region To promote research in endemic, hereditary and infectious ENT problems related to our region To expose and study impact of ethnic, social, environmental and cultural issues on expression of different ENT diseases To organize common epidemiologic research of value to the region To provide resource to national and regional authorities about problems in the field of ENT and their implication on public health and resources To facilitate exchange of knowledge in our part of the world To expand activities with regional and international scientific societies.