{"title":"Etude de la specificite sur la chaine b de l'insuline des cathepsines d et e de lapin","authors":"H. Rangel , C. Lapresle","doi":"10.1016/0926-6593(66)90184-6","DOIUrl":null,"url":null,"abstract":"<div><p>The action of rabbit cathepsins D and E on the B chain of beef insulin has been studied.</p><p>Cathepsin D hydrolyses the bonds Leu<sub>11</sub>-Val<sub>12</sub>, Glu<sub>13</sub>-Ala<sub>14</sub>, Ala<sub>14</sub>-Leu<sub>15</sub>, Leu<sub>15</sub>-Tyr<sub>16</sub>, Tyr<sub>16</sub>-Leu<sub>17</sub>, Leu<sub>17</sub>-Val<sub>18</sub>, Phe<sub>24</sub>-Phe<sub>25</sub>, Phe<sub>25</sub>-Tyr<sub>26</sub>, Tyr<sub>26</sub>-Thr<sub>27</sub>. Furthermore, it hydrolyses one of the bonds His<sub>5</sub>-Leu<sub>6</sub> or Leu<sub>6</sub>-Cys<sub>7</sub>, or both.</p><p>Cathepsin E hydrolyses the bonds Leu<sub>11</sub>-Val<sub>12</sub>, Glu<sub>13</sub>-Val<sub>14</sub>, Leu<sub>15</sub>-Tyr<sub>16</sub>, Tyr<sub>16</sub>-Leu<sub>17</sub>, Phe<sub>24</sub>-Phe<sub>25</sub>, Phe<sub>25</sub>-Tyr<sub>26</sub>.</p></div>","PeriodicalId":100160,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation","volume":"128 2","pages":"Pages 372-379"},"PeriodicalIF":0.0000,"publicationDate":"1966-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6593(66)90184-6","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926659366901846","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
The action of rabbit cathepsins D and E on the B chain of beef insulin has been studied.
Cathepsin D hydrolyses the bonds Leu11-Val12, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Leu17-Val18, Phe24-Phe25, Phe25-Tyr26, Tyr26-Thr27. Furthermore, it hydrolyses one of the bonds His5-Leu6 or Leu6-Cys7, or both.
Cathepsin E hydrolyses the bonds Leu11-Val12, Glu13-Val14, Leu15-Tyr16, Tyr16-Leu17, Phe24-Phe25, Phe25-Tyr26.
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