Synthesis, characterization and potent antimicrobial and antifungal activity of 2-substituted benzimidazole derivatives

IF 0.5 4区化学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry Pub Date : 2021-01-20 DOI:10.56042/ijcb.v60i01.31988

R. Verma, Chitra Guptab, Ali Mohd Ganieb, S. Singha, P. K. Singhc

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Abstract

Benzimidazole is the heterocyclic compound formed by the fusion of benzene and imidazole ring. Benzimidazole analogs are of great significance because of their clinical application and biological activity. Benzimidazoles are considered as an optimistic class of bioactive heterocyclic compound that possesses a range of biological activities. We have synthesized five substituted Benzimidazole derivative using on both microwave irradiation and conventional heating method. The newly synthesized compounds are characterized by IR, NMR and Mass spectra analysis. In the present study, we have reported the synthesis, spectral studies and biological evaluation of some benzimidazole derivatives. Benzimidazole play important role in medical field with so many pharmacological activities such as antimicrobial, anti bacterial, etc. The potency of this clinically useful drug in treatment in microbial action and other activities has encouraged the development of some more potent and significant compounds.

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2-取代苯并咪唑衍生物的合成、表征及有效的抗菌和抗真菌活性

苯并咪唑是由苯和咪唑环融合而成的杂环化合物。苯并咪唑类似物的临床应用和生物活性具有重要意义。苯并咪唑被认为是一类具有广泛生物活性的杂环化合物。采用微波辐照法和常规加热法合成了5个取代苯并咪唑衍生物。新合成的化合物通过IR、NMR和质谱分析进行了表征。本文报道了一些苯并咪唑衍生物的合成、光谱研究和生物学评价。苯并咪唑具有抗菌、抗菌等多种药理作用，在医学领域占有重要地位。这种临床上有用的药物在治疗微生物作用和其他活动方面的效力鼓励了一些更有效和更重要的化合物的开发。

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来源期刊

Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry 化学-有机化学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Indian Journal of Chemistry (Section B) is a leading monthly journal in Organic and Medicinal Chemistry started publishing from 1976. It publishes papers on organic reaction mechanism, theoretical organic chemistry, structure-activity relationships, medicinal chemistry, synthesis of chiral compounds, bio-organic chemistry, enzymes in organic synthesis, reagents in organic synthesis, heterocyclic compounds, phytochemistry (natural products), amino acids, peptides and proteins, spectroscopy in characterization of organic compounds, chemoenzymatic and enantioselective synthesis of organic compounds, synthesis of fullerenes, metal-catalyzed asymmetric reactions, bioactive plant products and combinatorial chemistry. Apart from full length papers, notes and communications, the journal publishes short reviews on frontline areas under the column " advances in Contemporary Research".