Are Vitamin D Levels Linked to Primary Monosymptomatic Nocturnal Enuresis in Children? Six Years of Experience about a Controversy in Medicine: A Case-control Study

IF 0.4 4区医学 Q4 PEDIATRICS

Iranian Journal of Pediatrics Pub Date : 2023-04-09 DOI:10.5812/ijp-133755

S. Siroosbakht

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引用次数: 2

Abstract

Background: The relationship between vitamin D and primary monosymptomatic nocturnal enuresis (PMNE) is still controversial. Objectives: This study aimed to investigate the relationship between different vitamin D levels with the development and severity of PMNE. Methods: A case-control study of 534 children (267 children with PMNE as the case group and 267 healthy children without enuresis as the control group), aged 6 - 15 years old, was conducted in two tertiary primary care hospitals, Tehran, Iran, from 2015 to 2021. The participants' demographic characteristics and vitamin D status were evaluated in both groups. The relationship between vitamin D levels with enuresis and its severity was studied as the main outcome measures. Multiple logistic regression models were utilized for statistical analyses to assay the odds ratio at a confidence interval of 95%. In this study, P < 0.05 were set as the significance level. Results: Vitamin D levels significantly differed between the two groups (18.58 ± 9.83 ng/mL and 30.23 ± 10.62 ng/mL, respectively; P < 0.001). After adjusting for confounders, vitamin D was significantly associated with enuresis (< 20 ng/mL, OR 3.07, 95% CI 1.9 - 4.95, P = 0.0001; 20 - 30 ng/mL, OR 2.72, 95% CI 1.47 - 3.67, P = 0.0001). Adjusted OR with 95% CI concerning the history of parental enuresis was 15.03 (95% CI 1.88 - 19.6, P = 0.01). The prevalence of vitamin D deficiency and insufficiency in the PMNE subjects were 107 cases (40.1%) and 109 cases (40.8%), respectively, and the prevalence values in the control group were 57 cases (21.3%) and 71 cases (26.6%), respectively (P < 0.05). Furthermore, the participants with higher frequencies of bedwetting represented lower vitamin D levels (severe, 10.6 ± 1.23 ng/ mL; moderate, 19.46 ± 1.21 ng/mL; mild, 26.8 ± 2.61 ng/mL, P = 0.0001). Conclusions: According to the finding of this study, parental history, and the participants’ vitamin D status were significant risk factors for the PMNE development. Vitamin D levels were significantly lower in the PMNE children. The prevalence of vitamin D deficiency and insufficiency was significantly higher in the enuretic subjects. Children with higher frequencies of bedwetting represented lower vitamin D levels.

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维生素D水平与儿童原发性单症状性夜间遗尿有关吗?医学争议的六年经验:一项病例对照研究

背景:维生素D与原发性单症状性夜间遗尿(PMNE)的关系仍有争议。目的:探讨不同维生素D水平与PMNE发生及严重程度的关系。方法:2015 - 2021年在伊朗德黑兰两所三级基层医院对534名6 - 15岁儿童进行病例对照研究，其中经PMNE患儿267例为病例组，无遗尿症健康患儿267例为对照组。对两组参与者的人口统计学特征和维生素D状况进行评估。研究了维生素D水平与遗尿症及其严重程度的关系。采用多元logistic回归模型进行统计分析，以95%的置信区间测定优势比。本研究以P < 0.05为显著性水平。结果:两组患者维生素D水平差异显著(分别为18.58±9.83 ng/mL和30.23±10.62 ng/mL);P < 0.001)。调整混杂因素后，维生素D与遗尿显著相关(< 20 ng/mL, OR 3.07, 95% CI 1.9 - 4.95, P = 0.0001;20 ~ 30 ng/mL, OR 2.72, 95% CI 1.47 ~ 3.67, P = 0.0001)。父母遗尿史的校正OR和95% CI为15.03 (95% CI 1.88 ~ 19.6, P = 0.01)。PMNE组维生素D缺乏和不足患病率分别为107例(40.1%)和109例(40.8%)，对照组患病率分别为57例(21.3%)和71例(26.6%)，差异有统计学意义(P < 0.05)。此外，尿床频率较高的参与者维生素D水平较低(严重，10.6±1.23 ng/ mL;中等，19.46±1.21 ng/mL;轻度，26.8±2.61 ng/mL, P = 0.0001)。结论:根据本研究的发现，父母史和参与者的维生素D状况是PMNE发展的重要危险因素。PMNE组儿童的维生素D水平明显较低。在尿毒症患者中，维生素D缺乏和不足的发生率明显更高。尿床频率较高的儿童体内维生素D含量较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pediatrics 医学-小儿科

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.