MXenes and MXene-based Materials with Cancer Diagnostic Applications: Challenges and Opportunities

IF 3.8 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Comments on Inorganic Chemistry Pub Date : 2021-10-25 DOI:10.1080/02603594.2021.1990890

Ghazaleh Jamalipour Soufi, Parisa Iravani, A. Hekmatnia, E. Mostafavi, M. Khatami, S. Iravani

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引用次数: 25

Abstract

ABSTRACT MXenes and MXene-based materials exhibited unique properties such as remarkable conductivity, hydrophilicity, high ion transport features, low diffusion barrier, biocompatibility, and suitable surface area, which make them promising candidates for sensing and imaging applications in the field of biomedicine (especially cancer diagnosis/imaging), analytical chemistry, and (bio)sensing. These two-dimensional (2D) materials with suitable surface functionalization or modification can be considered as the next-generation structures for cancer diagnosis with high biocompatibility, stability, and adoption capacity. In the field of cancer diagnosis and imaging, MXenes with great potentials and unique physicochemical structures should be further evaluated by researchers, especially for their biosafety, biocompatibility, stability, and biodegradability. Future studies should move toward specific clinical evaluations as well as industrial and up-scalable production of innovative functionalized MXenes and MXene-based materials with efficient cancer diagnostic potentials. In this review, recent advances related to the cancer diagnostic applications of MXenes and MXene-based materials are highlighted, focusing on current challenges and future perspectives. GRAPHICAL ABSTRACT

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MXenes和基于MXenes的材料与癌症诊断应用:挑战与机遇

MXenes和基于MXenes的材料具有优异的导电性、亲水性、高离子传输特性、低扩散屏障、生物相容性和合适的表面积等特性，在生物医学(特别是癌症诊断/成像)、分析化学和(生物)传感领域具有广阔的应用前景。这些具有合适的表面功能化或修饰的二维(2D)材料可以被认为是具有高生物相容性，稳定性和采用能力的下一代癌症诊断结构。在癌症诊断和成像领域，MXenes具有巨大的潜力和独特的物理化学结构，值得研究人员进一步评价，特别是其生物安全性、生物相容性、稳定性和生物降解性。未来的研究应该转向具体的临床评估，以及具有高效癌症诊断潜力的创新功能化MXenes和基于MXenes的材料的工业化和规模化生产。本文综述了MXenes和基于MXenes的材料在癌症诊断应用方面的最新进展，重点介绍了当前面临的挑战和未来的展望。图形抽象

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来源期刊

Comments on Inorganic Chemistry 化学-无机化学与核化学

CiteScore

9.00

自引率

1.90%

发文量

审稿时长

>12 weeks

期刊介绍： Comments on Inorganic Chemistry is intended as a vehicle for authoritatively written critical discussions of inorganic chemistry research. We publish focused articles of any length that critique or comment upon new concepts, or which introduce new interpretations or developments of long-standing concepts. “Comments” may contain critical discussions of previously published work, or original research that critiques existing concepts or introduces novel concepts. Through the medium of “comments,” the Editors encourage authors in any area of inorganic chemistry - synthesis, structure, spectroscopy, kinetics and mechanisms, theory - to write about their interests in a manner that is both personal and pedagogical. Comments is an excellent platform for younger inorganic chemists whose research is not yet widely known to describe their work, and add to the spectrum of Comments’ author profiles, which includes many well-established inorganic chemists.