Antidiabetic evaluation of methanolic extract of Lagerstroemia parviflora Roxb. in streptozotocin-induced diabetic Wistar albino rat model

Abstract

Objective: The objective of research paper was to evaluate the antidiabetic activity of methanolic extract of Lagerstroemia parviflora Roxb. (MELPR) in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The MELPR of different concentrations (200 and 300 mg/kg b.w.) was administered orally and evaluated for the estimation of biochemical parameters (serum glutamate pyruvate transaminase [SGPT], alkaline phosphatase [ALP]), skin and behavioral activity, oral glucose tolerance test and very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), VLDL cholesterol and LDL cholesterol (VLDL-C and LDL-C), and antidiabetic potential. Results and Discussion: The antidiabetic activities data indicate substantially altered physiological and biochemical aspects. In Lagerstroemia parviflora Roxb. (MELPR), the dose of 100 and 200 mg/kg shown the cholesterol level 138.0 mg/dl and 125.0 mg/dl as compared to standard drug glibenclamide which shown the cholesterol level 110.0 mg/dl at a dose of 500 mg/kg. Study result indicates that significant decrease in total cholesterol, triglyceride, and LDL cholesterol levels was observed after treating the STZ-induced diabetic rats with 200 and 300 mg/kg body weight leading to a significant increase in the cholesterol levels.Conclusion: In acute toxicity study, no toxic symptoms were observed for MELPR, up to dose 3000 mg/kg. The MELPR possesses hypoglycemic activity, which varies with concentration. In neutral and basic media, the hypoglycemic activity was considerably more than that in acidic media. This study demonstrates the antidiabetic potential of Lagerstroemia microcarpa Wight and offers scientific validation and basis to develop antidiabetic drug.