Increased antibacterial activity of Angelica koreana and Arnebia euchroma extracts fermented by Lactobacillus acidifarinae against methicillin-resistant Staphylococcus aureus

Abstract

The increasing epidemic of methicillin-resistant Staphylococcus aureus (MRSA), one of the most important hospital and community pathogens, has led to a demand for new agents to treat the infection. Natural products may be used to reduce this problem with low side effects. The objective of this study was to determine the antibacterial effect of fermented extracts of Angelica koreana and Arnebia euchroma by Lactobacillus spp. against S. aureus , which were tested by disk diffusion test. Extracts of A. koreana and A. euchroma showed a clear zone of 15.5 ± 1.1 and 15.9 ± 2.2 mm, respectively. Fermented extracts by Lactobacillus sp. showed more improved antibacterial activity against S. aureus than the extracts.